Functional microarray analysis suggests repressed cell-cell signaling and cell survival-related modules inhibit progression of head and neck squamous cell carcinoma

Table 3 Expression of genes found in altered modules of head and neck squamous cell carcinoma (HNSCC) assessed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).

Comparison	Gene	,p-value, Mann-Whitney test	Fold change
Positive lymph node (61 samples)	CCL20	0.009	3.40
X
Negative lymph node (20 samples)	EGFR	0.006	1.70
	INHBA	0.014	2.05
	IL1B	0.07	1.38
	SERPINA3	0.07	-2.43
	AKT1	0.13	-
	MYC	0.17	-
	MCM2	0.22	-
	AREG	0.41	-
	PCNA	0.43	-
	KLK6	0.45	-
	FOSB	0.59	-
Recurrent tumors (20 samples)	BST2	0.014	-1.70
X
Non-recurrent tumors (27 samples)	POSTN	0.058	2.47
	IL1F9	0.061	1.91
	CCL20	0.19	-
	INHBA	0.55	-
	AREG	0.67	-
	KLK6	0.76	-

HNSCC patients were classified according to pathologic lymph node status (positive or negative) or tumor recurrence (recurrent or non-recurrent tumor) after treatment (surgery with neck dissection followed by radiotherapy). Functional module analysis was performed on microarray gene expression data obtained from primary tumors. Expression of selected genes was assessed by qRT-PCR.

ISSN: 1755-8794