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Table 2 Top 40 overrepresented Gene Ontology biological processes (FDR < 0.0001) in alternatively spliced genes in stage 4+ vs. 1- tumors

From: Exon array analysis reveals neuroblastoma tumors have distinct alternative splicing patterns according to stage and MYCN amplification status

GO Term # Gene PValue
cell cycle process ** 203 2.26E-15
mitotic cell cycle ** 107 8.64E-15
cellular component organization and biogenesis * 572 1.07E-14
cell cycle ** 230 1.33E-14
cell cycle phase ** 115 2.03E-14
mitosis ** 84 2.29E-14
cell division ** 88 3.86E-14
M phase of mitotic cell cycle ** 84 4.03E-14
M phase ** 97 1.28E-13
organelle organization and biogenesis * 285 1.67E-13
developmental process 651 4.37E-12
nervous system development * 192 1.66E-10
multicellular organismal development 479 4.24E-10
cellular process 2167 4.71E-10
chromosome segregation 32 7.47E-10
anatomical structure development 441 1.43E-9
localization 610 1.10E-8
regulation of cell cycle ** 135 1.11E-8
cell cycle checkpoint 30 1.15E-8
cytoskeleton organization and biogenesis * 134 1.41E-8
system development 364 1.93E-8
regulation of progression through cell cycle ** 133 2.61E-8
DNA replication ** 74 7.81E-8
synaptic transmission * 84 2.63E-7
transmission of nerve pulse 93 2.98E-7
establishment of localization 533 5.36E-7
intracellular signaling cascade 307 6.77E-7
cell proliferation 179 7.05E-7
transport 516 7.30E-7
mitotic sister chromatid segregation 18 7.33E-7
response to DNA damage stimulus ** 86 1.18E-6
sister chromatid segregation 18 1.33E-6
biological adhesion * 173 1.67E-6
cell adhesion * 173 1.67E-6
DNA metabolic process ** 188 2.59E-6
cell communication 747 7.35E-6
interphase 34 1.15E-5
DNA replication initiation 16 2.45E-5
DNA-dependent DNA replication ** 36 2.54E-5
cell differentiation 355 2.55E-5
  1. * GO terms that are also enriched in alternatively spliced genes in stage 4- vs 1- tumors.
  2. ** GO terms that are also enriched in differentially expressed genes in stage 4- vs 1- tumors.
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