A large scale survey reveals that chromosomal copy-number alterations significantly affect gene modules involved in cancer initiation and progression

Table 2 GO terms corresponding to the "biological process" ontology significantly associated to chromosomal regions frequently amplified in cancers.

GO term	GO ID	Number of genes	p-value (FDR-adjusted)	p-value (Bonferroni-adjusted)
defense response to bacterium	GO:0042742	98	1.7594 × 10 ^-11	2.98 × 10 ^-11
mismatch repair	GO:0006298	27	0.003339	0.0020
xenobiotic metabolic process	GO:0006805	29	0.028646	0.169
defense response to fungus	GO:0050832	13	0.018143	0.101
telomere maintenance	GO:0000723	24	0.14336	0.303

GO terms with p-values under a conventional threshold of p < 0.05 are listed in boldface. Also, GO terms under a more liberal p < 0.15 are listed in normal face. Nominal p-values obtained by conducting the one-tailed test (see details in [14]) were adjusted for multiple testing using the FDR [34] and the more conservative Bonferroni corrections.

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