Figure 8

Transcript dysregulation prevented by insulin treatment. Genes which were confirmed in qPCR experiments to not be differentially expressed at one month but differentially expressed at three months in the diabetic but not the insulin-treated diabetic were classified as 'Prevented'. Increased expression of C1s, C1Inh, Carhspb1, Chi3L1, Hspb1, Icam1, Lgals3, and Timp1 was observed but completely prevented by one and a half months of insulin treatment. Similarly, decreased expression of Car14 and Drd5, was observed and prevented by insulin treatment. One-way ANOVA, Student Newman Keuls pair-wise post-hoc test, *P < 0.05, **P < 0.01, ***P < 0.001 for 3 month data; n = 7-11/group. ND - Non-Diabetic control, D - Diabetic, D+I - Insulin-treated Diabetic, 1 M - 1 month, 3 M - 3 Months.