Table 2 Prostate cells, stem cells, cancer cell lines and xenografts.
From: Lineage relationship of prostate cancer cell types based on gene expression
Cell type | Origin | Characteristics | AR status | PSA/KLK3 status |
|---|---|---|---|---|
Prostate cancer cell lines | ||||
LNCaP | Lymph node metastasis | Luminal | Mutant AR | Positive |
C4-2 | Derived from LNCaP through selection in castrated animals | Luminal | Mutant AR | Positive |
CL1 | Derived from LNCaP through selection in androgen-depleted media | Non-luminal-like | Negative | Negative |
PC3 | Bone metastasis | Non-luminal-like | Negative | Negative |
DU145 | Brain metastasis | Non-luminal-like | Negative | Negative |
Xenografts | ||||
LuCaP 35 | Lymph node metastasis, adenocarcinoma | Luminal-like | Positive | Positive |
LuCaP 49 | Omental metastasis, small cell carcinoma | Non-luminal-like | Negative | Negative |
Cells isolated from prostate tumor specimens | ||||
G3 | CD26+ Gleason pattern 3 from primary tumor, glandular | Luminal-like | Positive | Positive |
G4 | CD26+ Gleason pattern 4 from primary tumor, aglandular | Non-luminal-like | Positive | Positive |
Stem cell lines | ||||
NCCIT | Embryonal carcinoma | Negative | Negative | |
H1 | Embryonic stem cell | Negative | Negative | |
Cells isolated from normal prostate tissue specimens | ||||
Luminal (L) | CD26+ luminal epithelial | Positive | Positive | |
Basal (B) | CD104+ basal epithelial | Negative | Negative | |
Stromal (S) | CD49a+ stromal | Positive | Negative | |
Endothelial (E) | CD31+ endothelial | Negative | Negative | |
Progenitor (5D3) | ABCG2+ progenitor | Negative | Negative | |
Progenitor (SP) | Side population progenitor | Negative | Negative | |