Table 4 Ingenuity canonical pathways significantly (B-H p-value < 0.05) represented by the genes down-regulated in the common metastatic signature
Ingenuity Canonical Pathways | Fisher Exact p-value | B-H p-value | Ratio |
|---|---|---|---|
Actin Cytoskeleton Signaling | 7.94E-08 | 1.51E-05 | 4.26E-02 |
Regulation of Actin-based Motility by Rho | 3.89E-06 | 2.14E-04 | 6.52E-02 |
Integrin Signaling | 4.57E-06 | 2.14E-04 | 3.96E-02 |
Calcium Signaling | 2.24E-05 | 7.08E-04 | 3.41E-02 |
Protein Kinase A Signaling | 1.12E-04 | 3.02E-03 | 2.51E-02 |
RhoA Signaling | 1.86E-04 | 4.27E-03 | 4.55E-02 |
NRF2-mediated Oxidative Stress Response | 2.00E-04 | 4.27E-03 | 3.28E-02 |
ILK Signaling | 2.51E-04 | 4.68E-03 | 3.23E-02 |
Thrombin Signaling | 3.39E-04 | 5.75E-03 | 2.94E-02 |
Chemokine Signaling | 4.17E-04 | 6.61E-03 | 5.33E-02 |
VEGF Signaling | 8.32E-04 | 1.07E-02 | 4.12E-02 |
FAK Signaling | 8.71E-04 | 1.07E-02 | 4.00E-02 |
Phospholipase C Signaling | 9.12E-04 | 1.07E-02 | 2.34E-02 |
cAMP-mediated Signaling | 1.02E-03 | 1.15E-02 | 3.11E-02 |
Tight Junction Signaling | 1.15E-03 | 1.20E-02 | 2.99E-02 |
Relaxin Signaling | 3.47E-03 | 2.95E-02 | 2.68E-02 |
CDK5 Signaling | 9.12E-03 | 6.17E-02 | 3.19E-02 |
IL-8 Signaling | 9.33E-03 | 6.17E-02 | 2.15E-02 |