Skip to main content

Advertisement

Table 1 The most differential predicted secretome of adipose and liver tissues

From: Comparative analysis of the human hepatic and adipose tissue transcriptomes during LPS-induced inflammation leads to the identification of differential biological pathways and candidate biomarkers

ACC. NAME4 GENE AT FC AT p value AT avg - LPS AT avg + LPS AT std - LPS AT std + LPS LT FC LT p value LT avg - LPS LT avg + LPS LT std - LPS LT std + LPS
P01584 INTERLEUKIN 1, BETA IL1B 20 1, 18E-06 584, 3 11733, 8 496, 8 3295, 7 100 0, 0002 9, 5 957, 6 17, 6 305, 3
P10147 CHEMOKINE (C-C MOTIF) LIGAND 3 CCL3 19.8 2, 0E-07 239, 3 4732, 6 160, 7 2239, 1 10.7 0, 0088 48, 7 521, 6 55, 4 226, 4
Q96DR8 SMALL BREAST EPITHELIAL MUCIN MUCL1 17.4 5, 5E-05 36, 4 607, 9 20, 9 759, 2 5.8 0, 0008 5, 1 30, 0 2, 3 14, 8
P18510 INTERLEUKIN 1 RECEPTOR ANTAGONIST IL1RN 12.5 9, 4E-06 16, 6 207, 4 6, 3 164, 7 6.5 0, 0148 118, 4 768, 3 127, 8 1132, 3
P78556 CHEMOKINE (C-C MOTIF) LIGAND 20 CCL20 11.4 7, 2E-06 1602, 6 18245, 7 1844, 3 2070, 8 7.5 0, 0199 1149, 2 8631, 9 306, 4 1263, 2
P16619 CHEMOKINE (C-C MOTIF) LIGAND 3-LIKE 1 CCL3L1 10.7 3, 4E-07 49, 7 1715, 4 38, 6 894, 1 34.5 0, 0088 48, 7 521, 6 55, 4 226, 4
P42830 CHEMOKINE (C-X-C MOTIF) LIGAND 5 CXCL5 7.8 1, 5E-04 735, 9 5489, 8 1215, 8 2385, 3 30.3 0, 0000 13, 9 330, 5 1, 9 23, 3
P35354 PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2 PTGS2 6.8 5, 1E-05 1530, 5 10373, 9 1772, 5 2532, 4 7.9 0, 0478 39, 9 315, 1 3, 9 63, 5
P13501 CHEMOKINE (C-C MOTIF) LIGAND 5/RANTES CCL5 6.3 1, 4E-06 252, 5 1588, 3 190, 4 458, 9 68 0, 0002 15, 8 1074, 0 17, 0 1425, 3
P05120 SERPIN PEPTIDASE INHIBITOR SERPINB2 6 1, 1E-06 1825, 8 10909, 0 856, 7 2503, 1 8 0, 0022 25, 0 200, 7 37, 0 104, 9
P01583 INTERLEUKIN 1, ALPHA IL1A 5.8 4, 4E-04 343, 2 1979, 4 211, 1 820, 6 4.3 0, 0043 7, 3 32, 1 2, 3 4, 2
O14625 CHEMOKINE (C-X-C MOTIF) LIGAND 11 CXCL11 5.4 1, 3E-03 19, 1 102, 5 15, 9 63, 2 20.4 0, 0269 10, 5 214, 6 17, 2 1379, 4
P05231 INTERLEUKIN 6 (INTERFERON, BETA 2) IL6 4.5 2, 1E-05 4702, 1 21313, 8 3820, 2 1972, 7 17.8 0, 0097 40, 6 722, 6 52, 8 703, 0
P08254 MATRIX METALLOPEPTIDASE 3 MMP3 4 5, 5E-04 1333, 4 5331, 4 1458, 8 1982, 5 20.6 0, 0377 12, 2 251, 5 115, 5 725, 9
P09038 FIBROBLAST GROWTH FACTOR 2 (BASIC) FGF2 3.7 7, 1E-04 173, 4 642, 5 165, 2 200, 0 3.5 0, 0020 13, 7 48, 4 5, 5 32, 0
P39900 MATRIX METALLOPEPTIDASE 12 (MACROPHAGE ELASTASE) MMP12 3.7 1, 5E-04 22, 1 81, 7 8, 9 41, 1 5.8 0, 0220 19, 0 110, 8 31, 8 102, 9
P09341 CHEMOKINE (C-X-C MOTIF) LIGAND 1 CXCL1 3 1, 0E-03 4666, 1 14183, 2 5268, 4 3237, 7 23.5 0, 0013 70, 1 1648, 1 45, 5 615, 2
P02778 CHEMOKINE (C-X-C MOTIF) LIGAND 10 CXCL10 2.9 1, 4E-03 361, 5 1045, 7 248, 5 461, 4 17 0, 0431 72, 3 1234, 9 4543, 9 297, 8
P80162 CHEMOKINE (C-X-C MOTIF) LIGAND 6 CXCL6 2.8 1, 3E-03 2632, 1 7420, 4 2720, 0 1531, 1 22 0, 0033 20, 4 447, 3 49, 8 174, 3
P10144 GRANZYME B GZMB 2.8 5, 1E-04 31, 8 87, 9 8, 5 38, 9 6.1 0, 0253 11, 9 73, 1 7, 6 91, 3
O60462 NEUROPILIN 2 NRP2 2.6 7, 0E-06 25, 0 65, 5 9, 0 7, 5 2.6 0, 0211 27, 9 72, 7 4, 8 15, 3
P10145 INTERLEUKIN 8 IL8 2.5 2, 1E-03 9738, 0 23999, 7 7532, 4 1532, 3 6 0, 0038 358, 9 4271, 3 480, 9 1244, 2
P13500 CHEMOKINE (C-C MOTIF) LIGAND 2 CCL2 2.3 5, 1E-06 5528, 4 12745, 4 1561, 6 1659, 7 3.7 0, 0435 726, 0 2675, 4 321, 4 366, 3
P16581 SELECTIN E (ENDOTHELIAL ADHESION MOLECULE 1) SELE 105.1 1, 9E-06 5, 3 558, 7 4, 9 191, 7 4, 6 0, 6116 6, 9 31, 4 4, 7 31, 9
P04141 COLONY STIMULATING FACTOR 2 CSF2 82.5 1, 7E-07 9, 0 742, 5 12, 3 402, 4 1, 6 0, 4180 1, 6 2, 7 5, 2 2, 5
Q9BYE3 LATE CORNIFIED ENVELOPE 3D LCE3D 46 1, 2E-05 -2, 7 70, 3 4, 1 103, 9 -1, 2 0, 7820 8, 2 7, 0 5, 1 6, 7
P02763 OROSOMUCOID 1 ORM1 26.6 2, 3E-03 12, 4 329, 5 8, 8 470, 6 1, 0 0, 7173 4506, 7 4609, 2 1108, 8 582, 4
O14944 EPIREGULIN EREG 25 1, 8E-06 -3, 1 17, 1 4, 0 8, 7 -2, 0 0, 8984 2, 8 1, 3 2, 0 4, 5
P22894 MATRIX METALLOPEPTIDASE 8 (NEUTROPHIL COLLAGENASE) MMP8 22.2 1, 3E-03 2, 3 51, 3 5, 7 48, 1 1, 5 0, 4560 10, 6 15, 9 9, 7 18, 5
Q00604 NORRIE DISEASE (PSEUDOGLIOMA) NDP 19.5 3, 8E-07 15, 1 295, 4 13, 4 165, 2 1, 3 0, 9185 1, 5 1, 9 1, 6 2, 5
P07357 COMPLEMENT COMPONENT 8, ALPHA POLYPEPTIDE C8A 18.6 3, 6E-04 18, 6 345, 7 21, 4 179, 7 -1, 6 0, 5130 780, 6 481, 8 421, 3 165, 0
P78423 FRACTALCINE CX3CL1 6.4 5, 6E-07 97, 1 617, 8 29, 9 285, 0 9.9 0, 6235 23.4 232.5 14.3 431.9
P01375 TUMOR NECROSIS FACTOR (TNF SUPERFAMILY, MEMBER 2) TNF 6 3, 5E-10 28, 8 173, 4 5, 5 30, 3 1, 6 0, 9980 7, 8 12, 8 4, 4 7, 5
Q9UHD0 INTERLEUKIN 19 IL19 5.6 9, 7E-06 6, 2 34, 9 3, 0 13, 1 1, 8 0, 5200 -2, 0 -3, 4 3, 0 4, 8
P26022 PENTRAXIN-RELATED GENE, RAPIDLY INDUCED BY IL-1 BETA PTX3 4 1, 0E-04 992, 2 4000, 0 614, 4 1504, 4 2, 1 0, 6562 7, 5 15, 5 7, 2 7, 8
P03956 MATRIX METALLOPEPTIDASE 1 (INTERSTITIAL COLLAGENASE) MMP1 3.4 3, 0E-04 2662, 1 8995, 1 3099, 1 1471, 0 1, 0 0, 5981 928, 4 968, 5 1473, 1 441, 9
Q9BY76 ANGIOPOIETIN-LIKE 4 ANGPTL4 3.2 2, 9E-03 83, 8 268, 7 45, 7 139, 2 2, 0 0, 5980 70, 6 137, 9 34, 0 156, 1
P19875 CHEMOKINE (C-X-C MOTIF) LIGAND 2 CXCL2 3.1 7, 3E-04 1753, 9 5471, 3 1121, 4 1569, 5 1, 4 0, 4725 13, 7 19, 1 5, 3 5, 8
P05121 SERPIN PEPTIDASE INHIBITOR/PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1) MEMBER 1 SERPINE1/
pai1
3 6, 1E-04 3110, 0 9426, 1 2165, 8 2364, 8 1, 7 0, 7450 64, 6 108, 5 29, 1 81, 8
P10124 PROTEOGLYCAN 1, SECRETORY GRANULE SRGN 2.7 3, 2E-05 3141, 4 8426, 4 1107, 6 2008, 1 1, 1 1, 0000 3, 4 3, 6 3, 0 1, 5
Q96RQ9 INTERLEUKIN 4 INDUCED 1 IL4I1 2.4 2, 4E-03 132, 4 318, 9 73, 6 149, 7 -1, 6 0, 7500 -1, 2 -0, 8 3, 5 5, 1
Q9Y5U4 INSULIN INDUCED GENE 2 INSIG2 2.3 8, 5E-04 316, 7 722, 0 129, 6 225, 9 -1, 2 0, 8880 94, 3 79, 9 38, 4 11, 1
P12643 BONE MORPHOGENETIC PROTEIN 2 BMP2 2.2 3, 4E-04 1131, 3 2465, 7 472, 0 655, 5 1, 7 0, 6915 91, 6 158, 3 103, 2 87, 3
P02735 SERUM AMYLOID A1 SAA1 2.2 2, 2E-03 355, 1 778, 1 165, 9 246, 5 1, 1 0, 9120 4896, 1 5144, 0 564, 6 238, 5
Q07325 CHEMOKINE (C-X-C MOTIF) LIGAND 9 CXCL9 1.8 5, 5E-02 207, 1 376, 4 231, 9 233, 9 69.3 0, 0009 33, 0 2288, 5 66, 7 3090, 5
P19876 CHEMOKINE (C-X-C MOTIF) LIGAND 3 CXCL3 3.6 9, 6E-03 15, 5 56, 0 7, 9 29, 7 20.6 0, 0050 28, 1 587, 5 8, 9 300, 0
O95633 FOLLISTATIN-LIKE 3 (SECRETED GLYCOPROTEIN) FSTL3 1 9, 3E-01 687, 0 665, 4 224, 2 136, 2 15.1 0, 0036 32, 8 495, 5 86, 8 378, 1
Q13113 PDZK1 INTERACTING PROTEIN 1 PDZK1IP1 1.9 2, 3E-01 43, 0 84, 2 25, 9 54, 7 12.9 0, 0010 13, 0 169, 4 51, 6 168, 3
Q9NRD8 DUAL OXIDASE 2 DUOX2 -2 3, 5E-01 4, 9 2, 3 2, 9 3, 8 5.5 0, 0084 77, 2 428, 5 49, 2 154, 2
Q8WWX9 SELENOPROTEIN M SELM 1.6 5, 2E-03 2336, 5 3877, 9 840, 8 945, 4 3.9 0, 0025 114, 1 445, 5 37, 0 79, 2
O94808 GLUTAMINE-FRUCTOSE-6-PHOSPHATE TRANSAMINASE 2 GFPT2 1.7 1, 3E-04 2797, 3 4808, 3 419, 1 945, 3 3.6 0, 0019 15, 1 54, 6 3, 3 2, 7
P13164 INTERFERON INDUCED TRANSMEMBRANE PROTEIN 1 (9-27) IFITM1 - 1.1 7, 3E-01 2134, 1 1986, 2 785, 1 682, 9 3.5 0, 0435 375, 2 1318, 2 462, 2 466, 0
P09603 COLONY STIMULATING FACTOR 1 (MACROPHAGE) CSF1 - 1.6 3, 0E-02 128, 4 73, 4 53, 5 28, 0 3.3 0, 0056 73, 4 242, 7 19, 3 118, 7
P12544 GRANZYME A GZMA - 1.4 2, 2E-01 123, 1 85, 7 55, 7 25, 5 3.3 0, 0215 6, 7 21, 9 3, 6 27, 1
P25774 CATHEPSIN S CTSS 1.4 1, 2E-02 135, 5 194, 8 43, 5 31, 0 3.2 0, 0168 270, 5 881, 9 86, 8 355, 9
P24001 INTERLEUKIN 32 IL32 1.6 5, 0E-06 551, 7 888, 2 42, 1 121, 3 3 0, 0061 2723, 6 8331, 0 668, 1 472, 2
P31431 SYNDECAN 4 (AMPHIGLYCAN, RYUDOCAN) SDC4 1.9 1, 5E-02 1049, 2 1962, 3 453, 7 796, 4 2.7 0, 0111 1141, 2 3088, 8 160, 0 643, 0
P03973 SECRETORY LEUKOCYTE PEPTIDASE INHIBITOR SLPI - 1.4 1, 0E+00 1063, 8 755, 9 946, 2 387, 2 2.7 0, 0050 1505, 1 4153, 1 255, 9 660, 6
P09237 MATRIX METALLOPEPTIDASE 7 (MATRILYSIN, UTERINE) MMP7 - 1.6 4, 2E-01 7, 9 4, 5 13, 2 15, 1 2.6 0, 0244 8, 7 22, 8 12, 3 34, 0
Q5VY09 IMMEDIATE EARLY RESPONSE 5 IER5 1.6 4, 7E-03 471, 5 780, 8 99, 5 258, 3 2.5 0, 0215 139, 5 347, 3 79, 7 90, 2
O75976 CARBOXYPEPTIDASE D CPD 1.3 1, 2E-01 761, 1 1012, 4 282, 7 315, 0 2.2 0, 0335 54, 8 118, 9 47, 3 51, 3
  1. Fold change (FC) for the highest and significantly upregulated genes (p ≤ 0.05) upon LPS treatment (+LPS) compared to control (-LPS) in adipose tissue (AT), n = 7 and liver tissue (LT) n = 5 are indicated in bold and are underlined. FCs for not significantly changed genes in both tissues (p > 0.05) are in italics. Additionally, information about average (avg) gene expression value and it's standard deviation (std) for both AT and LT is given.