Table 1 The most differential predicted secretome of adipose and liver tissues
ACC. | NAME4 | GENE | AT FC | AT p value | AT avg - LPS | AT avg + LPS | AT std - LPS | AT std + LPS | LT FC | LT p value | LT avg - LPS | LT avg + LPS | LT std - LPS | LT std + LPS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P01584 | INTERLEUKIN 1, BETA | IL1B | 20 | 1, 18E-06 | 584, 3 | 11733, 8 | 496, 8 | 3295, 7 | 100 | 0, 0002 | 9, 5 | 957, 6 | 17, 6 | 305, 3 |
P10147 | CHEMOKINE (C-C MOTIF) LIGAND 3 | CCL3 | 19.8 | 2, 0E-07 | 239, 3 | 4732, 6 | 160, 7 | 2239, 1 | 10.7 | 0, 0088 | 48, 7 | 521, 6 | 55, 4 | 226, 4 |
Q96DR8 | SMALL BREAST EPITHELIAL MUCIN | MUCL1 | 17.4 | 5, 5E-05 | 36, 4 | 607, 9 | 20, 9 | 759, 2 | 5.8 | 0, 0008 | 5, 1 | 30, 0 | 2, 3 | 14, 8 |
P18510 | INTERLEUKIN 1 RECEPTOR ANTAGONIST | IL1RN | 12.5 | 9, 4E-06 | 16, 6 | 207, 4 | 6, 3 | 164, 7 | 6.5 | 0, 0148 | 118, 4 | 768, 3 | 127, 8 | 1132, 3 |
P78556 | CHEMOKINE (C-C MOTIF) LIGAND 20 | CCL20 | 11.4 | 7, 2E-06 | 1602, 6 | 18245, 7 | 1844, 3 | 2070, 8 | 7.5 | 0, 0199 | 1149, 2 | 8631, 9 | 306, 4 | 1263, 2 |
P16619 | CHEMOKINE (C-C MOTIF) LIGAND 3-LIKE 1 | CCL3L1 | 10.7 | 3, 4E-07 | 49, 7 | 1715, 4 | 38, 6 | 894, 1 | 34.5 | 0, 0088 | 48, 7 | 521, 6 | 55, 4 | 226, 4 |
P42830 | CHEMOKINE (C-X-C MOTIF) LIGAND 5 | CXCL5 | 7.8 | 1, 5E-04 | 735, 9 | 5489, 8 | 1215, 8 | 2385, 3 | 30.3 | 0, 0000 | 13, 9 | 330, 5 | 1, 9 | 23, 3 |
P35354 | PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2 | PTGS2 | 6.8 | 5, 1E-05 | 1530, 5 | 10373, 9 | 1772, 5 | 2532, 4 | 7.9 | 0, 0478 | 39, 9 | 315, 1 | 3, 9 | 63, 5 |
P13501 | CHEMOKINE (C-C MOTIF) LIGAND 5/RANTES | CCL5 | 6.3 | 1, 4E-06 | 252, 5 | 1588, 3 | 190, 4 | 458, 9 | 68 | 0, 0002 | 15, 8 | 1074, 0 | 17, 0 | 1425, 3 |
P05120 | SERPIN PEPTIDASE INHIBITOR | SERPINB2 | 6 | 1, 1E-06 | 1825, 8 | 10909, 0 | 856, 7 | 2503, 1 | 8 | 0, 0022 | 25, 0 | 200, 7 | 37, 0 | 104, 9 |
P01583 | INTERLEUKIN 1, ALPHA | IL1A | 5.8 | 4, 4E-04 | 343, 2 | 1979, 4 | 211, 1 | 820, 6 | 4.3 | 0, 0043 | 7, 3 | 32, 1 | 2, 3 | 4, 2 |
O14625 | CHEMOKINE (C-X-C MOTIF) LIGAND 11 | CXCL11 | 5.4 | 1, 3E-03 | 19, 1 | 102, 5 | 15, 9 | 63, 2 | 20.4 | 0, 0269 | 10, 5 | 214, 6 | 17, 2 | 1379, 4 |
P05231 | INTERLEUKIN 6 (INTERFERON, BETA 2) | IL6 | 4.5 | 2, 1E-05 | 4702, 1 | 21313, 8 | 3820, 2 | 1972, 7 | 17.8 | 0, 0097 | 40, 6 | 722, 6 | 52, 8 | 703, 0 |
P08254 | MATRIX METALLOPEPTIDASE 3 | MMP3 | 4 | 5, 5E-04 | 1333, 4 | 5331, 4 | 1458, 8 | 1982, 5 | 20.6 | 0, 0377 | 12, 2 | 251, 5 | 115, 5 | 725, 9 |
P09038 | FIBROBLAST GROWTH FACTOR 2 (BASIC) | FGF2 | 3.7 | 7, 1E-04 | 173, 4 | 642, 5 | 165, 2 | 200, 0 | 3.5 | 0, 0020 | 13, 7 | 48, 4 | 5, 5 | 32, 0 |
P39900 | MATRIX METALLOPEPTIDASE 12 (MACROPHAGE ELASTASE) | MMP12 | 3.7 | 1, 5E-04 | 22, 1 | 81, 7 | 8, 9 | 41, 1 | 5.8 | 0, 0220 | 19, 0 | 110, 8 | 31, 8 | 102, 9 |
P09341 | CHEMOKINE (C-X-C MOTIF) LIGAND 1 | CXCL1 | 3 | 1, 0E-03 | 4666, 1 | 14183, 2 | 5268, 4 | 3237, 7 | 23.5 | 0, 0013 | 70, 1 | 1648, 1 | 45, 5 | 615, 2 |
P02778 | CHEMOKINE (C-X-C MOTIF) LIGAND 10 | CXCL10 | 2.9 | 1, 4E-03 | 361, 5 | 1045, 7 | 248, 5 | 461, 4 | 17 | 0, 0431 | 72, 3 | 1234, 9 | 4543, 9 | 297, 8 |
P80162 | CHEMOKINE (C-X-C MOTIF) LIGAND 6 | CXCL6 | 2.8 | 1, 3E-03 | 2632, 1 | 7420, 4 | 2720, 0 | 1531, 1 | 22 | 0, 0033 | 20, 4 | 447, 3 | 49, 8 | 174, 3 |
P10144 | GRANZYME B | GZMB | 2.8 | 5, 1E-04 | 31, 8 | 87, 9 | 8, 5 | 38, 9 | 6.1 | 0, 0253 | 11, 9 | 73, 1 | 7, 6 | 91, 3 |
O60462 | NEUROPILIN 2 | NRP2 | 2.6 | 7, 0E-06 | 25, 0 | 65, 5 | 9, 0 | 7, 5 | 2.6 | 0, 0211 | 27, 9 | 72, 7 | 4, 8 | 15, 3 |
P10145 | INTERLEUKIN 8 | IL8 | 2.5 | 2, 1E-03 | 9738, 0 | 23999, 7 | 7532, 4 | 1532, 3 | 6 | 0, 0038 | 358, 9 | 4271, 3 | 480, 9 | 1244, 2 |
P13500 | CHEMOKINE (C-C MOTIF) LIGAND 2 | CCL2 | 2.3 | 5, 1E-06 | 5528, 4 | 12745, 4 | 1561, 6 | 1659, 7 | 3.7 | 0, 0435 | 726, 0 | 2675, 4 | 321, 4 | 366, 3 |
P16581 | SELECTIN E (ENDOTHELIAL ADHESION MOLECULE 1) | SELE | 105.1 | 1, 9E-06 | 5, 3 | 558, 7 | 4, 9 | 191, 7 | 4, 6 | 0, 6116 | 6, 9 | 31, 4 | 4, 7 | 31, 9 |
P04141 | COLONY STIMULATING FACTOR 2 | CSF2 | 82.5 | 1, 7E-07 | 9, 0 | 742, 5 | 12, 3 | 402, 4 | 1, 6 | 0, 4180 | 1, 6 | 2, 7 | 5, 2 | 2, 5 |
Q9BYE3 | LATE CORNIFIED ENVELOPE 3D | LCE3D | 46 | 1, 2E-05 | -2, 7 | 70, 3 | 4, 1 | 103, 9 | -1, 2 | 0, 7820 | 8, 2 | 7, 0 | 5, 1 | 6, 7 |
P02763 | OROSOMUCOID 1 | ORM1 | 26.6 | 2, 3E-03 | 12, 4 | 329, 5 | 8, 8 | 470, 6 | 1, 0 | 0, 7173 | 4506, 7 | 4609, 2 | 1108, 8 | 582, 4 |
O14944 | EPIREGULIN | EREG | 25 | 1, 8E-06 | -3, 1 | 17, 1 | 4, 0 | 8, 7 | -2, 0 | 0, 8984 | 2, 8 | 1, 3 | 2, 0 | 4, 5 |
P22894 | MATRIX METALLOPEPTIDASE 8 (NEUTROPHIL COLLAGENASE) | MMP8 | 22.2 | 1, 3E-03 | 2, 3 | 51, 3 | 5, 7 | 48, 1 | 1, 5 | 0, 4560 | 10, 6 | 15, 9 | 9, 7 | 18, 5 |
Q00604 | NORRIE DISEASE (PSEUDOGLIOMA) | NDP | 19.5 | 3, 8E-07 | 15, 1 | 295, 4 | 13, 4 | 165, 2 | 1, 3 | 0, 9185 | 1, 5 | 1, 9 | 1, 6 | 2, 5 |
P07357 | COMPLEMENT COMPONENT 8, ALPHA POLYPEPTIDE | C8A | 18.6 | 3, 6E-04 | 18, 6 | 345, 7 | 21, 4 | 179, 7 | -1, 6 | 0, 5130 | 780, 6 | 481, 8 | 421, 3 | 165, 0 |
P78423 | FRACTALCINE | CX3CL1 | 6.4 | 5, 6E-07 | 97, 1 | 617, 8 | 29, 9 | 285, 0 | 9.9 | 0, 6235 | 23.4 | 232.5 | 14.3 | 431.9 |
P01375 | TUMOR NECROSIS FACTOR (TNF SUPERFAMILY, MEMBER 2) | TNF | 6 | 3, 5E-10 | 28, 8 | 173, 4 | 5, 5 | 30, 3 | 1, 6 | 0, 9980 | 7, 8 | 12, 8 | 4, 4 | 7, 5 |
Q9UHD0 | INTERLEUKIN 19 | IL19 | 5.6 | 9, 7E-06 | 6, 2 | 34, 9 | 3, 0 | 13, 1 | 1, 8 | 0, 5200 | -2, 0 | -3, 4 | 3, 0 | 4, 8 |
P26022 | PENTRAXIN-RELATED GENE, RAPIDLY INDUCED BY IL-1 BETA | PTX3 | 4 | 1, 0E-04 | 992, 2 | 4000, 0 | 614, 4 | 1504, 4 | 2, 1 | 0, 6562 | 7, 5 | 15, 5 | 7, 2 | 7, 8 |
P03956 | MATRIX METALLOPEPTIDASE 1 (INTERSTITIAL COLLAGENASE) | MMP1 | 3.4 | 3, 0E-04 | 2662, 1 | 8995, 1 | 3099, 1 | 1471, 0 | 1, 0 | 0, 5981 | 928, 4 | 968, 5 | 1473, 1 | 441, 9 |
Q9BY76 | ANGIOPOIETIN-LIKE 4 | ANGPTL4 | 3.2 | 2, 9E-03 | 83, 8 | 268, 7 | 45, 7 | 139, 2 | 2, 0 | 0, 5980 | 70, 6 | 137, 9 | 34, 0 | 156, 1 |
P19875 | CHEMOKINE (C-X-C MOTIF) LIGAND 2 | CXCL2 | 3.1 | 7, 3E-04 | 1753, 9 | 5471, 3 | 1121, 4 | 1569, 5 | 1, 4 | 0, 4725 | 13, 7 | 19, 1 | 5, 3 | 5, 8 |
P05121 | SERPIN PEPTIDASE INHIBITOR/PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1) MEMBER 1 | SERPINE1/ pai1 | 3 | 6, 1E-04 | 3110, 0 | 9426, 1 | 2165, 8 | 2364, 8 | 1, 7 | 0, 7450 | 64, 6 | 108, 5 | 29, 1 | 81, 8 |
P10124 | PROTEOGLYCAN 1, SECRETORY GRANULE | SRGN | 2.7 | 3, 2E-05 | 3141, 4 | 8426, 4 | 1107, 6 | 2008, 1 | 1, 1 | 1, 0000 | 3, 4 | 3, 6 | 3, 0 | 1, 5 |
Q96RQ9 | INTERLEUKIN 4 INDUCED 1 | IL4I1 | 2.4 | 2, 4E-03 | 132, 4 | 318, 9 | 73, 6 | 149, 7 | -1, 6 | 0, 7500 | -1, 2 | -0, 8 | 3, 5 | 5, 1 |
Q9Y5U4 | INSULIN INDUCED GENE 2 | INSIG2 | 2.3 | 8, 5E-04 | 316, 7 | 722, 0 | 129, 6 | 225, 9 | -1, 2 | 0, 8880 | 94, 3 | 79, 9 | 38, 4 | 11, 1 |
P12643 | BONE MORPHOGENETIC PROTEIN 2 | BMP2 | 2.2 | 3, 4E-04 | 1131, 3 | 2465, 7 | 472, 0 | 655, 5 | 1, 7 | 0, 6915 | 91, 6 | 158, 3 | 103, 2 | 87, 3 |
P02735 | SERUM AMYLOID A1 | SAA1 | 2.2 | 2, 2E-03 | 355, 1 | 778, 1 | 165, 9 | 246, 5 | 1, 1 | 0, 9120 | 4896, 1 | 5144, 0 | 564, 6 | 238, 5 |
Q07325 | CHEMOKINE (C-X-C MOTIF) LIGAND 9 | CXCL9 | 1.8 | 5, 5E-02 | 207, 1 | 376, 4 | 231, 9 | 233, 9 | 69.3 | 0, 0009 | 33, 0 | 2288, 5 | 66, 7 | 3090, 5 |
P19876 | CHEMOKINE (C-X-C MOTIF) LIGAND 3 | CXCL3 | 3.6 | 9, 6E-03 | 15, 5 | 56, 0 | 7, 9 | 29, 7 | 20.6 | 0, 0050 | 28, 1 | 587, 5 | 8, 9 | 300, 0 |
O95633 | FOLLISTATIN-LIKE 3 (SECRETED GLYCOPROTEIN) | FSTL3 | 1 | 9, 3E-01 | 687, 0 | 665, 4 | 224, 2 | 136, 2 | 15.1 | 0, 0036 | 32, 8 | 495, 5 | 86, 8 | 378, 1 |
Q13113 | PDZK1 INTERACTING PROTEIN 1 | PDZK1IP1 | 1.9 | 2, 3E-01 | 43, 0 | 84, 2 | 25, 9 | 54, 7 | 12.9 | 0, 0010 | 13, 0 | 169, 4 | 51, 6 | 168, 3 |
Q9NRD8 | DUAL OXIDASE 2 | DUOX2 | -2 | 3, 5E-01 | 4, 9 | 2, 3 | 2, 9 | 3, 8 | 5.5 | 0, 0084 | 77, 2 | 428, 5 | 49, 2 | 154, 2 |
Q8WWX9 | SELENOPROTEIN M | SELM | 1.6 | 5, 2E-03 | 2336, 5 | 3877, 9 | 840, 8 | 945, 4 | 3.9 | 0, 0025 | 114, 1 | 445, 5 | 37, 0 | 79, 2 |
O94808 | GLUTAMINE-FRUCTOSE-6-PHOSPHATE TRANSAMINASE 2 | GFPT2 | 1.7 | 1, 3E-04 | 2797, 3 | 4808, 3 | 419, 1 | 945, 3 | 3.6 | 0, 0019 | 15, 1 | 54, 6 | 3, 3 | 2, 7 |
P13164 | INTERFERON INDUCED TRANSMEMBRANE PROTEIN 1 (9-27) | IFITM1 | - 1.1 | 7, 3E-01 | 2134, 1 | 1986, 2 | 785, 1 | 682, 9 | 3.5 | 0, 0435 | 375, 2 | 1318, 2 | 462, 2 | 466, 0 |
P09603 | COLONY STIMULATING FACTOR 1 (MACROPHAGE) | CSF1 | - 1.6 | 3, 0E-02 | 128, 4 | 73, 4 | 53, 5 | 28, 0 | 3.3 | 0, 0056 | 73, 4 | 242, 7 | 19, 3 | 118, 7 |
P12544 | GRANZYME A | GZMA | - 1.4 | 2, 2E-01 | 123, 1 | 85, 7 | 55, 7 | 25, 5 | 3.3 | 0, 0215 | 6, 7 | 21, 9 | 3, 6 | 27, 1 |
P25774 | CATHEPSIN S | CTSS | 1.4 | 1, 2E-02 | 135, 5 | 194, 8 | 43, 5 | 31, 0 | 3.2 | 0, 0168 | 270, 5 | 881, 9 | 86, 8 | 355, 9 |
P24001 | INTERLEUKIN 32 | IL32 | 1.6 | 5, 0E-06 | 551, 7 | 888, 2 | 42, 1 | 121, 3 | 3 | 0, 0061 | 2723, 6 | 8331, 0 | 668, 1 | 472, 2 |
P31431 | SYNDECAN 4 (AMPHIGLYCAN, RYUDOCAN) | SDC4 | 1.9 | 1, 5E-02 | 1049, 2 | 1962, 3 | 453, 7 | 796, 4 | 2.7 | 0, 0111 | 1141, 2 | 3088, 8 | 160, 0 | 643, 0 |
P03973 | SECRETORY LEUKOCYTE PEPTIDASE INHIBITOR | SLPI | - 1.4 | 1, 0E+00 | 1063, 8 | 755, 9 | 946, 2 | 387, 2 | 2.7 | 0, 0050 | 1505, 1 | 4153, 1 | 255, 9 | 660, 6 |
P09237 | MATRIX METALLOPEPTIDASE 7 (MATRILYSIN, UTERINE) | MMP7 | - 1.6 | 4, 2E-01 | 7, 9 | 4, 5 | 13, 2 | 15, 1 | 2.6 | 0, 0244 | 8, 7 | 22, 8 | 12, 3 | 34, 0 |
Q5VY09 | IMMEDIATE EARLY RESPONSE 5 | IER5 | 1.6 | 4, 7E-03 | 471, 5 | 780, 8 | 99, 5 | 258, 3 | 2.5 | 0, 0215 | 139, 5 | 347, 3 | 79, 7 | 90, 2 |
O75976 | CARBOXYPEPTIDASE D | CPD | 1.3 | 1, 2E-01 | 761, 1 | 1012, 4 | 282, 7 | 315, 0 | 2.2 | 0, 0335 | 54, 8 | 118, 9 | 47, 3 | 51, 3 |