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Table 3 Functions and canonical pathways as differentially expressed up-regulated genes in ob/ob vs. WT, with no significant changes in POKO vs. WT mice

From: Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass

Top Bio Functions   
Name p-value # Molecules
Diseases and Disorders   
Immunological Disease 7.66E-18 - 3.63E-03 250
Inflammatory Disease 5.95E-15 - 3.60E-03 263
InflammatoryResponse 2.28E-14 - 3.63E-03 144
Skeletal and Muscular Disorders 4.99E-12 - 3.63E-03 255
Connective Tissue Disorders 7.78E-12 - 2.44E-03 175
Molecular and Cellular Functions   
Cellular Development 1.45E-17 - 4.37E-03 197
Cellular Function and Maintenance 2.21E-15 - 3.58E-03 103
Cell-To-Cell Signaling and Interaction 9.41E-15 - 4.37E-03 202
Cellular Growth and Proliferation 3.93E-13 - 3.11E-03 173
Cellular Movement 1.94E-09 - 3.78E-03 143
Physiological System Development and Function   
Hematological System Development and Function 3.63E-16 - 4.04E-03 189
Hematopoiesis 3.63E-16 - 3.27E-03 112
Tissue Morphology 2.59E-15 - 3.60E-03 124
Cell-mediated Immune Response 1.22E-14 - 3.78E-03 92
Immune Cell Trafficking 2.25E-13 - 3.78E-03 118
Top Canonical Pathways   
Name p-value Ratio
Autoimmune Thyroid Disease Signaling 3.06E-13 17/61 (0.279)
Allograft Rejection Signaling 1.49E-12 16/59 (0.271)
Type I Diabetes Mellitus Signaling 4.79E-12 27/119 (0.227)
Graft-versus-Host Disease Signaling 3.57E-10 15/49 (0.306)
B Cell Development 8.43E-10 12/37 (0.324)
  1. Functions and canonical pathways identified by IPA as differentially expressed up regulated genes in islets from ob/ob vs. WT mice (fold change ≥ 1; P ≤ 0.05), with no significant changes in islets from POKO vs. WT mice.
  2. Note: p value was calculated using the Benjamini-Hochberg method of multiple testing correction. In the case of canonical pathways "Ratio" indicates the number of differentially expressed genes in a given pathway, divided by total number of genes that make up that pathway.