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Table 3 Candidate genes whose methylation is correlated with birth weight

From: DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?

Data Set L1-regularized regression R2 1 Non-zero regressions/total "leave one out" regressions at maximum L1 R2 Tissue Genes in model Gene ID
22 newborns, methylation at 1,536 CpGs assayed using Illumina's GoldenGate array 0.78 21/22 Blood APOE Apolipoprotein E
     MSX1 Msh homeobox 1
    Placenta GRB10 Growth factor receptor-bound protein 10
     PGRMC1 Progesterone receptor membrane component 1
     RGS14 Regulator of G-protein signaling 14
     SHMT2 Serine hydroxymethyl transferase 2 (mitochondrial)
48 newborns, methylation at 27,578 CpGs assayed using Illumina's Infinium array 0.50 44/48 Blood and placenta, as above Six genes, above  
48 newborns, methylation at 27,578 CpGs assayed using Illumina's Infinium array 0.70 45/48 Blood ATP6AP1 Atpase, H + transporting, lysosomal accessory protein 1
     PRSS21 Protease, serine, 21 (testisin)
     RCOR1 REST co-repressor 1
    Placenta ANGPT4 Angiopoietin 4
     CDK2 Cyclin-dependent kinase 2
     EVPL Envoplakin
     NAT8L FLJ37478: N-acetyltransferase 8-like (GCN5-related, putative)
48 newborns, methylation at 27,578 CpGs assayed using Illumina's Infinium array 0.84 44/48 Blood and Placenta, as above All 13 genes from both experiments, combined  
  1. 1 The maximum L1-regularized regression correlation obtained for the gene model in which more than 90% of the "leave one out" cross-validations exhibited non-zero regression parameters (third column)