DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?

Table 7 Five random permutation models with higher R² than the L₁ model and the adjusted R² when tested on the Infinium data-set

Data Set	R²	Adjusted R² and stability when tested on Infinium Data	Genes in model	Gene names
22 newborns, methylation at 1,536 CpGs assayed using Illumina's GoldenGate array	0.86	0.59 (46/48)	ADAM9	ADAM metallopeptidase domain 9
			DPYSL3	dihydropyrimidinase-like 3
			FABP5	fatty acid binding protein 5
			HOXB4	homeobox B4
			MHC2TA	CIITA, class II, major histocompatibility complex, transactivator
			PRO1853	C2orf56, chromosome 2 open reading frame 56
	0.82	negative	GRB10	growth factor receptor-bound protein 10
			HRASLS3	PLA2G16, phospholipase A2, group XVI
			MYH14	myosin, heavy chain 14, non-muscle
			NM15555
			WNT16	wingless-type MMTV integration site family, member 16
	0.81	0.48 (44/48)	BEST1	bestrophin 1
			IMPDH2	IMP (inosine 5'-monophosphate) dehydrogenase 2
			OSBPL5	oxysterol binding protein-like 5
			PAX3	paired box 3
			PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3
			SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
	0.80	0 (45/48)	CBX1	chromobox homolog 1
			EOMES	eomesodermin
			PABPC4	poly(A) binding protein, cytoplasmic 4 (inducible form)
			PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide
			SLC16A1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
			TMPO	thymopoietin
	0.79	negative	C11ORF15	TMEM9B, TMEM9 domain family, member B
			CCT3	chaperonin containing TCP1, subunit 3 (gamma)
			MYH9	myosin, heavy chain 9, non-muscle
			PROX1	prospero homeobox 1
			REST	RE1-silencing transcription factor
			RPS2	ribosomal protein S2

ISSN: 1755-8794