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Table 3 Association of apoptosis SNPs with aggressive prostate cancer

From: Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer

Marker (Alleles
and position)
Allele Cases N (%) Controls N (%) OR (95%CI) Adj OR (95%CI)* p value Bonf.
p value
p trend Permut.
p value
AKT3 CC 295 (42.9) 244 (50.0) 1.00 (reference) 1.00 (reference) 0.065 1.000 0.028 1.000
rs10157763 TC 307 (44.7) 192 (39.3) 1.31 (1.02-1.67) 1.33 (1.04-1.71) 0.027    
C240321082T TT 75 (10.9) 45 (9.2) 1.21 (0.82-1.78) 1.39 (0.92-2.09) 0.344    
  TC + TT 382 (55.6) 237 (48.6) 1.32 (1.04-1.66) 1.34 (1.06-1.70) 0.020 1.000   0.943
AKT3 GG 438 (63.8) 345 (70.7) 1.00 (reference) 1.00 (reference) 0.005 0.853 0.038 0.493
rs10927067 AG 227 (33.0) 119 (24.4) 1.50 (1.15-1.95) 1.51 (1.16-1.96) 0.002    
G240249285A AA 20 (2.9) 19 (3.9) 0.83 (0.44-1.58) 0.82 (0.43-1.57) 0.568    
  AG + AA 247 (36.0) 138 (28.3) 1.43 (1.12-1.84) 1.41 (1.10-1.82) 0.005 0.977   0.511
AKT3 TT 483 (70.3) 380 (77.9) 1.00 (reference) 1.00 (reference) 0.002 0.356 0.023 0.250
rs12031994 TC 192 (27.9) 94 (19.3) 1.61 (1.21-2.13) 1.61 (1.22-2.14) 0.009    
T240243350C CC 13 (1.9) 14 (2.9) 0.73 (0.34-1.57) 0.73 (0.34-1.57) 0.422    
  TC + CC 205 (29.8) 108 (22.1) 1.51 (1.15-1.98) 1.50 (0.15-1.96) 0.003 0.548   0.372
AKT3 GG 436 (63.5) 341 (69.9) 1.00 (reference) 1.00 (reference) 0.030 1.000 0.068 0.984
rs2125230 AG 231 (33.6) 129 (26.4) 1.40 (1.09-1.81) 1.40 (1.08-1.82) 0.010    
G240211889A AA 21 (3.1) 18 (3.7) 0.91 (0.48-1.74) 0.91 (0.48-1.74) 0.781    
  AG + AA 252 (36.7) 147 (30.1) 1.35 (1.06-1.73) 1.34 (1.05-1.72) 0.017 1.000   0.938
AKT3 GG 296 (43.1) 238 (48.8) 1.00 (reference) 1.00 (reference) 0.083 1.000 0.027 1.000
rs2125231 AG 314 (45.7) 203 (41.6) 1.24 (0.97-1.59) 1.25 (0.98-1.60) 0.082    
G240088340A AA 75 (10.9) 42 (8.6) 1.43 (0.95-2.17) 1.44 (0.95-2.18) 0.087    
  AG + AA 389 (56.6) 245 (50.2) 1.29 (1.02-1.63) 1.28 (1.01-1.62) 0.031 1.000   0.992
AKT3 CC 295 (42.9) 243 (49.8) 1.00 (reference) 1.00 (reference) 0.060 1.000 0.022 1.000
rs2345994 TC 312 (45.4) 195 (40.0) 1.32 (1.03-1.69) 1.32 (1.03-1.70) 0.028    
C240258316T TT 78 (11.4) 45 (9.2) 1.43 (0.95-2.14) 1.44 (0.95-2.16) 0.084    
  TC + TT 390 (56.8) 240 (49.2) 1.32 (1.05-1.67) 1.35 (1.06-1.70) 0.018 1.000   0.946
AKT3 CC 435 (63.3) 348 (71.3) 1.00 (reference) 1.00 (reference) 0.009 1.000 0.029 0.714
rs4132509 AC 227 (33.0) 121 (24.8) 1.50 (1.15-1.95) 1.51 (1.16-1.96) 0.002    
C240269125A AA 18 (2.6) 16 (3.3) 0.90 (0.45-1.79) 0.88 (0.44-1.75) 0.764    
  AC + AA 245 (35.7) 137 (28.1) 1.43 (1.11-1.84) 1.44 (1.11-1.85) 0.005 1.000   0.581
BCL2L14 GG 436 (63.5) 343 (70.3) 1.00 (reference) 1.00 (reference) 0.041 1.000 0.025 0.998
rs885720 AG 231 (33.6) 131 (26.8) 1.39 (1.07-1.79) 1.39 (1.08-1.80) 0.012    
G12139366A AA 21 (3.1) 14 (2.9) 1.18 (0.59-2.25) 1.20 (0.60-2.39) 0.639    
  AG + AA 252 (36.7) 145 (29.7) 1.37 (1.07-1.76) 1.37 (1.07-1.76) 0.013 1.000   0.843
CARD8 CC 462 (67.2) 362 (74.2) 1.00 (reference) 1.00 (reference) 0.016 1.000 0.005 0.882
rs10405717 TC 202 (29.4) 111 (22.7) 1.45 (1.11-1.90) 1.45 (1.11-1.90) 0.007    
C53443620T TT 21 (3.1) 10 (2.0) 1.70 (0.79-3.68) 1.70 (0.79-3.68) 0.173    
  TC + TT 223 (32.5) 121 (24.8) 1.45 (1.12-1.89) 1.47 (1.13-1.91) 0.005 0.754   0.459
IKBKE TT 251 (36.5) 209 (42.8) 1.00 (reference) 1.00 (reference) 0.008 1.000 0.003 0.682
rs11578093 TG 332 (48.3) 233 (47.7) 1.19 (0.93-1.52) 1.17 (0.91-1.50) 0.177    
T203059049G GG 102 (6.0) 46 (9.4) 1.85 (1.25-2.74) 1.81 (1.22-2.69) 0.002    
  TG + GG 434 (63.2) 279 (57.2) 1.31 (1.03-1.66) 1.27 (1.00-1.62) 0.027 1.000   0.982
IKBKE CC 502 (73.1) 341 (69.9) 1.00 (reference) 1.00 (reference) 0.048 1.000 0.076 1.000
rs1539243 TC 172 (25.0) 125 (25.6) 0.93 (0.71-1.22) 0.95 (0.73-1.24) 0.622    
C203036182T TT 14 (2.0) 22 (4.5) 0.43 (0.22-0.86) 0.44 (0.22-0.88) 0.016    
  TC + TT 186 (27.1) 147 (30.1) 0.86 (0.66-1.11) 0.88 (0.68-1.13) 0.244 1.000   1.000
PIK3CB TT 215 (31.3) 131 (26.8) 1.00 (reference) 1.00 (reference) 0.060 1.000 0.021 1.000
rs500687 TC 334 (48.6) 234 (48.0) 0.87 (0.66-1.14) 0.87 (0.66-1.14) 0.318    
T139942901C CC 134 (19.5) 121 (24.8) 0.67 (0.49-0.94) 0.66 (0.48-0.92) 0.019    
  TC + CC 468 (68.1) 355 (72.7) 0.81 (0.62-1.04) 0.80 (0.62-1.03) 0.099 1.000   1.000
RAF1 TT 508 (73.9) 377 (77.3) 1.00 (reference) 1.00 (reference) 0.010 1.000 0.473 0.764
rs13060691 TG 167 (24.3) 90 (18.4) 1.38 (1.03-1.84) 1.38 (1.03-1.84) 0.030    
T12653013G GG 10 (1.5) 16 (3.3) 0.44 (0.20-0.97) 0.45 (0.20-1.01) 0.060    
  TG + GG 177 (25.8) 106 (21.7) 1.24 (0.94-1.63) 1.24 (0.94-1.63) 0.123 1.000   1.000
  1. Abbreviations: Bonf., Bonferroni correction; Permut., Permutation; *adjusted for age and family history of PCA (PCA)