Figure 2From: A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy TOP2A index predicts response to anthracycline containing chemotherapy. A) Experimental strategy to identify the TOP2A index. B) TOP2A co-expressed probesets within the three discovery cohorts. C) Experimental strategy to validate the TOP2A index. D) ROC Analysis of TOP2A index scores and response to T/FAC neoadjuvant chemotherapy (AUC: 0.73, p < 0.0001). E) TOP2A index scores of patients who experienced pCR or had RD after neoadjuvant chemotherapy ( p < 0.0001, t-test).Back to article page