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Table 3 Prediction Results for three test sets.

From: Molecular prediction for atherogenic risks across different cell types of leukocytes

  No. of genes for prediction T-test (P-value) Sensitivity (%) Specificity (%) PPV (%) NPV (%) Youden index
56 gene model        
FH2 56 0.011 70.0 84.6 77.8 78.6 0.55
FH3 56 0.010 80.0 100 100 0.83 0.8
ATHRO1 56 0.019 71.4 71.4 71.4 71.4 0.43
COXEN model        
  48 0.0024 70.0 92.3 87.5 80.0 0.62
  6 1.5e-10 100 100.0 100.0 100 1.00
  25 0.010 78.6 66.7 68.8 76.9 0.45
  1. Data sets FH2, FH3, and ATHERO1 were used to evaluate the classification performance of our atherosclerosis prediction model. We tested if the predicted risk of atherosclerosis could statistically discriminate familial hypercholesterolemia or general atherosclerosis patients with normal people in these test sets. The statistical significance of the difference in predicted scores (COXEN SCORE) was evaluated using the two-sample t-test between patients and normal groups. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were also calculated.