Molecular prediction for atherogenic risks across different cell types of leukocytes

BMC Medical Genomics

Table 3 Prediction Results for three test sets.

	No. of genes for prediction	T-test (P-value)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Youden index
56 gene model
FH2	56	0.011	70.0	84.6	77.8	78.6	0.55
FH3	56	0.010	80.0	100	100	0.83	0.8
ATHRO1	56	0.019	71.4	71.4	71.4	71.4	0.43
COXEN model
	48	0.0024	70.0	92.3	87.5	80.0	0.62
	6	1.5e-10	100	100.0	100.0	100	1.00
	25	0.010	78.6	66.7	68.8	76.9	0.45

Data sets FH2, FH3, and ATHERO1 were used to evaluate the classification performance of our atherosclerosis prediction model. We tested if the predicted risk of atherosclerosis could statistically discriminate familial hypercholesterolemia or general atherosclerosis patients with normal people in these test sets. The statistical significance of the difference in predicted scores (COXEN SCORE) was evaluated using the two-sample t-test between patients and normal groups. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were also calculated.

ISSN: 1755-8794