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Table 2 Association of AC1/AC2 subgroups in external AC data sets with smoking history

From: Relation between smoking history and gene expression profiles in lung adenocarcinomas

Data set

Nbr NS/smokers*

Nbr NS/CS/FS*

Nbr NS classified as AC1

% smokers classified as AC1 (All/CS/FS)

Fisher’s exact test P-value **

DCC

49/300

49/32/268

45 (92%)

53/31/55

4 × 10−8/0.01

GSE10072

16/42

16/24/18

15 (94%)

55/46/67

0.005/0.22

GSE12667

8/43

8/18/25

8 (100%)

49/33/60

0.007/0.12

Beer et al.

9/72

9/NA/NA

8 (89%)

53/NA/NA

0.07/NA

GSE11969

45/45

45/NA/NA

37 (82%)

58/NA/NA

0.02/NA

GSE32863

29/29

29/29/0

23 (79%)

38/38/NA

0.003/NA

  1. * NS: never-smoker, CS: current smoker, FS: former smoker.
  2. ** Calculated from a 2×2 contingency table summarizing number of never-smokers and smokers for each AC subgroup (first p-value), or number of CS and FS for each AC subgroup (second p-value).