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Table 4 Association of the AC1/AC2 and DCC signature with smoking history in normal airway epithelial samples, and adjacent lung tissue

From: Relation between smoking history and gene expression profiles in lung adenocarcinomas

Data set Number NS/S/CS/FS* Number NS classified as AC1 % S/CS/FS classified as AC1 P-value AC1/AC2 classification** Number correctly identified NS by DCC signature*** % S/CS/FS classified as never-smokers by DCC signature P-value DCC classification**
GSE19027 8/44/24/20 7 (88%) 55/54/55 0.12 8 (100%) 45/21/75 0.005
GSE7895 21/83/52/31 16 (76%) 37/23/61 0.003 16 (76%) 42/40/45 0.007
GSE19667 48/73/NA/NA 38 (79%) 33/NA/NA 8 × 10−7 31 (65%) 33/NA/NA 0.0008
GSE11952 38/45/45/0 29 (76%) 29/29/0 2 × 10−5 21 (55%) 38/38/0 0.13
GSE32863A 30/28/28/0 23 (77%) 39/39/0 0.007 24 (80%) 39/39/0 0.003
GSE10072A 15/34/16/18 12 (80%) 44/38/50 0.03 13 (87%) 44/38/50 0.01
  1. * NS: never-smoker, S: smoker, CS: current smoker, FS: former smoker.
  2. ** Fisher’s exact P-value calculated from a 2×2 contingency table summarizing number of never-smokers and smokers for each classification group.
  3. *** NS classified as never-smoker by the classifier.
  4. A Adjacent normal lung tissue data set.