Figure 6

Expanded network of the validated miRNA–mRNA interactions. The network was generated using Ingenuity Pathway Analysis® tool. The validated network shown in Figure 5 was expanded to include experimentally validated interactions with our list of the 222 predicted miRNA targets (Additional file 4: Table S4). Green molecules are the four down regulated miRNAs (miR-133a/miR-133b, miR-204, and miR-331-3p), yellow molecules are experimentally verified target genes of the four miRNAs, and grey molecules are predicted targets of the four miRNAs. Solid lines represent direct connections and dashed lines represent indirect connections