Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative study

Mille-Hamard, Laurence; Billat, Veronique L; Henry, Elodie; Bonnamy, Blandine; Joly, Florence; Benech, Philippe; Barrey, Eric

doi:10.1186/1755-8794-5-29

Table 4 List of significantly down-regulated genes expressed in the tibialis anterior and soleus muscles in EPO-d mice and control mice

From: Skeletal muscle alterations and exercise performance decrease in erythropoietin-deficient mice: a comparative study

Genes	Entrez Gene ID	Normalized ratio	t-test P-value	Description
Ckm	12715	0.52	0.00	creatine kinase, muscle
Eno3	13808	0.53	0.01	enolase 3, beta muscle
Serpinb2	18788	0.57	0.04	serine (or cysteine) peptidase inhibitor, clade B, member 2
Apool	68117	0.58	0.02	apolipoprotein O-like
Hspb7	29818	0.58	0.03	heat shock protein family, member 7 (cardiovascular)
Chac1	69065	0.60	0.04	ChaC, cation transport regulator-like 1 (E. coli)
Cln3	12752	0.61	0.01	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
Nrap	18175	0.63	0.00	nebulin-related anchoring protein
Zyg11b	414872	0.63	0.00	zyg-ll homolog B (C. elegans)
Zp2	22787	0.65	0.00	zona pellucida glycoprotein 2
Atp1a2	98660	0.66	0.01	ATPase, Na+/K + transporting, alpha 2 polypeptide
Ctsd	13033	0.66	0.00	cathepsin D
Lrrc42	77809	0.66	0.01	leucine rich repeat containing 42
Ppp3ca	19055	0.67	0.01	protein phosphatase 3, catalytic subunit, alpha isoform
1600014E20Rik	71995	0.67	0.04	endogenous retroviral sequence 3
Kcnb1	16500	0.67	0.02	potassium voltage gated channel, Shab-related subfamily, member 1
1700052M18Rik	78415	0.68	0.04	RIKEN cDNA 1700052M18 gene
C1qtnf4	67445	0.68	0.03	C1q and tumor necrosis factor related protein 4
Setd3	52690	0.68	0.05	SET domain containing 3
Rtn2	20167	0.69	0.01	reticulon 2 (Z-band associated protein)
1110018H23Rik	68509	0.69	0.01	RIKEN cDNA 1110018H23 gene
Mgat2	217664	0.69	0.03	mannoside acetylglucosaminyltransferase 2
Smpd1	20597	0.70	0.02	sphingomyelin phosphodiesterase 1, acid lysosomal
Tbcc	72726	0.71	0.02	tubulin-specific chaperone c
Zfand5	22682	0.72	0.01	zinc finger, AN1-type domain 5
Tuba8	53857	0.72	0.02	tubulin, alpha 8
Fndc5	384061	0.73	0.02	fibronectin type III domain containing 5
Magea5	17141	0.73	0.04	melanoma antigen, family A, 5
Actg2	11468	0.73	0.03	actin, gamma 2, smooth muscle, enteric
Galnt14	71685	0.74	0.01	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14
2610019E17Rik	75614	0.74	0.01	RIKEN cDNA 2610019E17 gene
Scn4b	399548	0.74	0.00	sodium channel, type IV, beta
Olfr1370	258528	0.74	0.03	olfactory receptor 1370
Cbln2	12405	0.74	0.02	cerebellin 2 precursor protein
4933406C10Rik	74076	0.74	0.04	RIKEN cDNA 4933406C10 gene
Zfp618	72701	0.75	0.00	zinc fingerprotein 618
Slc2a4	6517	0.75	0.01	solute carrier family 2 (facilitated glucose transporter), member 4 [ Homo sapiens ]
Stx3	20908	0.75	0.01	syntaxin 3
Mdh2	4191	0.75	0.03	malate dehydrogenase 2, NAD (mitochondrial) [ Homo sapiens ]
Chchd6	66098	0.75	0.05	coiled-coil-helix-coiled-coil-helix domain containing 6
Gpsn2	106529	0.75	0.00	glycoprotein, synaptic 2
D230014K01Rik	217364	0.76	0.02	RIKEN cDNA D230014K01 gene
Zfp286	192651	0.76	0.04	zinc finger protein 286
Pctk1	18555	0.76	0.03	PCTAIRE-motif protein kinase 1
1700008N11Rik	75442	0.76	0.03	RIKEN cDNA 1700008N11 gene
1700015C15Rik	75532	0.76	0.02	RIKEN cDNA 1700015C15 gene
Uqcrc1	22273	0.76	0.00	ubiquinol-cytochrome c reductase core protein 1
Abi3	66610	0.77	0.02	ABI gene family, member 3
Vat1	26949	0.77	0.00	vesicle amine transport protein 1 homolog (T californica)
Snw1	66354	0.77	0.04	SNW domain containing 1
Eef1a2	13628	0.77	0.01	eukaryotic translation elongation factor 1 alpha 2
Nme5	75533	0.77	0.01	expressed in non-metastatic cells 5
Fxyd1	56188	0.77	0.03	FXYD domain-containing ion transport regulator 1
1700039E22Rik	73322	0.77	0.01	RIKEN cDNA 1700039E22 gene
Herpud1	64209	0.77	0.02	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Pms2	18861	0.77	0.04	postmeiotic segregation increased 2 (S. cerevisiae)
Gli3	14634	0.77	0.05	GLI-Kruppel family member GLI3
Eef2	13629	0.78	0.01	eukaryotic translation elongation factor 2
Perld1	320655	0.78	0.03	per1-like domain containing 1
Pbxip1	229534	0.78	0.01	pre-B-cell leukemia transcription factor interacting protein 1
Ncf1	17969	0.78	0.03	neutrophil cytosolic factor 1
Olfr745	258296	0.78	0.03	olfactory receptor 745
Wfikkn2	278507	0.78	0.01	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Syngr2	20973	0.78	0.01	synaptogyrin 2
Eml4	78798	0.78	0.04	echinoderm microtubule associated protein like 4
4930564G21Rik	75321	0.78	0.03	RIKEN cDNA 4930564G21 gene
B230217C12Rik	68127	0.78	0.02	RIKEN cDNA B230217C12 gene
1810054G18Rik	75660	0.78	0.00	lin-37 homolog (C. elegans)
Psmd4	19185	0.78	0.01	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Rab14	68365	0.78	0.04	RAB14, member RAS oncogene family
Slc15a4	100561	0.78	0.03	solute carrier family 15, member 4
Rcl1	59028	0.79	0.03	RNA terminal phosphate cyclase-like 1
Ndufa3	66091	0.79	0.01	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3
Tpmt	22017	0.79	0.02	thiopurine methyltransferase
Twf2	23999	0.79	0.01	twinfilin, actin-binding protein, homolog 2 (Drosophila)
Rbpjl	19668	0.79	0.01	recombination signal binding protein for immunoglobulin kappa J region-like
Gngt2	14710	0.79	0.04	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
Lmln	239833	0.79	0.03	leishmanolysin-like (metallopeptidase M8 family)
Olfr1433	258680	0.79	0.01	olfactory receptor 1433
2210404E10Rik	72305	0.79	0.02	RIKEN cDNA 2210404E10 gene
Sod1	20655	0.79	0.05	superoxide dismutase 1, soluble
2310007L24Rik	75573	0.79	0.02	RIKEN cDNA 2310007L24 gene
Asrgl1	66514	0.79	0.00	asparaginase like 1
Wdr54	75659	0.79	0.02	WD repeat domain 54
Ociad2	433904	0.79	0.01	OCIA domain containing 2
Atg9a	245860	0.79	0.05	autophagy-related 9A (yeast)
Rbm38	56190	0.79	0.01	RNA binding motif protein 38
Psmb5	19173	0.79	0.02	proteasome (prosome, macropain) subunit, beta type 5
Slc30a9	109108	0.79	0.03	solute carrier family 30 (zinc transporter), member 9
Agr2	23795	0.79	0.02	anterior gradient 2 (Xenopus laevis)
Cpne3	70568	0.79	0.01	copine III
Tbc1d1	57915	0.80	0.03	TBC1 domain family, member 1
Cacng6	54378	0.80	0.04	calcium channel, voltage-dependent, gamma subunit 6
5730494M16Rik	66648	0.80	0.01	RIKEN cDNA 5730494M16 gene
Olfr127	258374	0.80	0.03	olfactory receptor 127
4933408N05Rik	71122	0.80	0.03	RIKEN cDNA 4933408N05 gene
4930547E14Rik	75145	0.80	0.01	RIKEN cDNA 4930547E14 gene
Dhrs1	52585	0.80	0.00	dehydrogenase/reductase (SDR family) member 1
Bcat2	12036	0.80	0.01	branched chain aminotransferase 2, mitochondrial
1700012J22Rik	75496	0.80	0.04	RIKEN cDNA 1700012J22 gene
Efcbp2	117148	0.80	0.00	EF hand calcium binding protein 2
Rab23	19335	0.80	0.02	RAB23, member RAS oncogene family
Gpld1	14756	0.80	0.00	glycosylphosphatidylinositol specific phospholipase D1
Tomm40	53333	0.80	0.05	translocase of outer mitochondrial membrane 40 homolog (yeast)
Tln1	21894	0.80	0.01	talin 1
Tsc22d4	78829	0.80	0.01	TSC22 domain family 4
Dnahc1	110084	0.80	0.03	dynein, axonemal, heavy chain 1
1700128I11Rik	73615	0.80	0.03	RIKEN cDNA 1700128I11 gene
Tcf4	21413	0.80	0.01	transcription factor 4

A p-value <0.05 indicates that the expression ratio differed significantly from 1.

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ISSN: 1755-8794

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