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Table 2 Putative target genes of differentially expressed miRNAs in NPC biopsies, which was consistent with the mRNA expression
| miRNA microarray | cDNA microarray | ||
|---|---|---|---|
| miRNA | Expression | Target gene | expression |
| hsa-miR-1/206 | up | API5, PCDH17, SMAD2, MTSS1, PDCD10, PDCD4, SMAD4 | down |
| hsa-miR-141 | up | PDCD4, MTSS1, ARHGAP24, SIAH1, PTEN | down |
| hsa-miR-149 | up | TP63, SMAD2, CNTNAP2 | down |
| hsa-miR-18a/b | up | DICER1, GIGYF2, STK4, RABGAP1, NOTCH2, NEDD9, ATM, SMAD2, NAV1, FOSL2, CAMKK2, STK4, BTG3, UBE2Z, IRF2, LIN54, HIF1A, RABGAP1, CCDC88A, ETV6, CCND2 | down |
| hsa-miR-205 | up | CADM1, MORF4L2, PTEN, SMAD1, SMAD4, TP53BP2 | down |
| hsa-miR-544 | up | AKT2, CADM1, CDH1, SMAD4 | down |
| hsa-miR-99a/b | up | BMPR2, IGF1R, THAP2 | down |
| hsa-miR-203 | down | BCL2L2, ESR1, HBEGF, HBP1, HSPB8, IGFBP5, ITGA2, LPP, MAP3K1 MKL2, MLLT4, SOCS3 | up |
| hsa-miR-222 | down | ESR1, ITGB8, MBD2, MIA3, MLL, SOCS3, TET2 | up |
| hsa-miR-29a/c | down | BCL2L2, HBEGF, HBP1, HSPG2, ITGB1, LAMC2, LTBR, MIB1, MLF1, MMP2, NDST1, SVEP1 | up |
| hsa-miR-34b | down | BTRC, CTNNA1, CUL3, CYLD, ESR1, HIPK1, ITGA2, ITM2B, MKL2, MXD1, PAPD5, PPP1CB, SMAD3 | up |
| hsa-miR-34c-3p | down | DCBLD2, FOXN3, IKZF1, NPTN PAFAH1B1, USP10, YY1 | up |
| hsa-miR-34c-5p | down | ARHGAP1, ARHGEF3, BCL11B, C16orf5, CNTNAP1, FOXN3, FUT8, IL6R, ITGB8, ITSN1, JAG1, MLL2, NDST1, NOTCH2, NPNT, PPFIA1, PTPRM, PVRL1, SERPINE1, VCL, YY1 | up |
| hsa-miR-429 | down | MIB1, MLL5, NDST1, RHOA, RND3 | up |
