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Table 1 Patient characteristics

From: PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers

Variable Training set data n = 154 Total (%) Variable Test set data n = 814 Total (%)
Age (years) Median 55.5 Age (years) Median 50.4
  (range) 26 – >92   (range) 23.1 – 76.2
Menopausal status Pre 49 (31.8) Menopausal status Pre 439 (53.9)
  Post 101 (65.6)   Post 375 (46.1)
  Unknown 4 (2.6)    
Primary tumor size T1 63 (40.9) Primary tumor size T1 338 (41.5)
  T2 69 (44.8)   T2 430 (52.8)
  T3 17 (11.0)   T3 46 (5.7)
  Unknown 1 (0.6)    
  Reduction Mamoplasty 4 (2.6)    
Nodal status 0 95 (61.7) Nodal status 0 0
  1 – 3 54 (35.1)   1 – 3 503 (61.8)
  > 3 0 (0)   > 3 311 (38.2)
  Unknown 1 (0.6)    
  Reduction Mamoplasty 4 (2.6)    
Histopathologic grade* G1 23 (14.9) Histopathologic grade* G1 107 (13.1)
  G2 45 (29.2)   G2 335 (41.2)
  G3 80 (51.9)   G3 313 (38.5)
  GX 2 (1.3)   GX 59 (7.2)
  Reduction Mamoplasty 4 (2.6)    
Estrogen receptor^ Positive 100 (64.9) Estrogen receptor^ Positive 644 (79.1)
  Negative 49 (31.8)   Negative 170 (20.9)
  Unknown 1 (0.6)    
  Reduction Mamoplasty 4 (2.6)    
Progesterone receptor^^ Positive 82 (53.2) Progesterone receptor^^ Positive 567 (69.7)
  Negative 67 (43.5)   Negative 247 (30.3)
  Unknown 1 (0.6)    
  Reduction Mamoplasty 4 (2.6)    
HER2 status Positive 37 (24.0) HER2 status Positive 116 (14.3)
  Negative 111 (72.1)   Negative 698 (85.7)
  Unknown 2 (1.3)    
  Reduction Mamoplasty 4 (2.6)    
Ki67 IHC Unknown 154 (100) Ki67 IHC Positive 236 (29.6)
     Negative 561 (70.4)
PAM50 Intrinsic Subtype Luminal A 53 (34.4) PAM50 Intrinsic Subtype Luminal A 277 (34.0)
  Luminal B 27 (17.5)   Luminal B 261 (32.1)
  HER2-enriched 32 (20.8)   HER2-enriched 174 (21.4)
  Basal-like 38 (24.7)   Basal-like 70 (8.6)
  Normal-like 4 (2.6)   Normal-like 32 (3.9)
  1. *Grade based on Nottingham-Bloom-Richardson scoring.
  2. ^ER positive required at least 10% staining nuclei.
  3. ^^PR positive required at least 10% staining nuclei.
  4. #HER2 positive were 3+ IHC or 2+ and CISH confirmed.