Table 1 Patient characteristics
From: PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers
Variable | Training set data | n = 154 Total (%) | Variable | Test set data | n = 814 Total (%) |
|---|---|---|---|---|---|
Age (years) | Median | 55.5 | Age (years) | Median | 50.4 |
(range) | 26 – >92 | (range) | 23.1 – 76.2 | ||
Menopausal status | Pre | 49 (31.8) | Menopausal status | Pre | 439 (53.9) |
Post | 101 (65.6) | Post | 375 (46.1) | ||
Unknown | 4 (2.6) | ||||
Primary tumor size | T1 | 63 (40.9) | Primary tumor size | T1 | 338 (41.5) |
T2 | 69 (44.8) | T2 | 430 (52.8) | ||
T3 | 17 (11.0) | T3 | 46 (5.7) | ||
Unknown | 1 (0.6) | ||||
Reduction Mamoplasty | 4 (2.6) | ||||
Nodal status | 0 | 95 (61.7) | Nodal status | 0 | 0 |
1 – 3 | 54 (35.1) | 1 – 3 | 503 (61.8) | ||
> 3 | 0 (0) | > 3 | 311 (38.2) | ||
Unknown | 1 (0.6) | ||||
Reduction Mamoplasty | 4 (2.6) | ||||
Histopathologic grade* | G1 | 23 (14.9) | Histopathologic grade* | G1 | 107 (13.1) |
G2 | 45 (29.2) | G2 | 335 (41.2) | ||
G3 | 80 (51.9) | G3 | 313 (38.5) | ||
GX | 2 (1.3) | GX | 59 (7.2) | ||
Reduction Mamoplasty | 4 (2.6) | ||||
Estrogen receptor^ | Positive | 100 (64.9) | Estrogen receptor^ | Positive | 644 (79.1) |
Negative | 49 (31.8) | Negative | 170 (20.9) | ||
Unknown | 1 (0.6) | ||||
Reduction Mamoplasty | 4 (2.6) | ||||
Progesterone receptor^^ | Positive | 82 (53.2) | Progesterone receptor^^ | Positive | 567 (69.7) |
Negative | 67 (43.5) | Negative | 247 (30.3) | ||
Unknown | 1 (0.6) | ||||
Reduction Mamoplasty | 4 (2.6) | ||||
HER2 status | Positive | 37 (24.0) | HER2 status | Positive | 116 (14.3) |
Negative | 111 (72.1) | Negative | 698 (85.7) | ||
Unknown | 2 (1.3) | ||||
Reduction Mamoplasty | 4 (2.6) | ||||
Ki67 IHC | Unknown | 154 (100) | Ki67 IHC | Positive | 236 (29.6) |
Negative | 561 (70.4) | ||||
PAM50 Intrinsic Subtype | Luminal A | 53 (34.4) | PAM50 Intrinsic Subtype | Luminal A | 277 (34.0) |
Luminal B | 27 (17.5) | Luminal B | 261 (32.1) | ||
HER2-enriched | 32 (20.8) | HER2-enriched | 174 (21.4) | ||
Basal-like | 38 (24.7) | Basal-like | 70 (8.6) | ||
Normal-like | 4 (2.6) | Normal-like | 32 (3.9) |