Table 1 GO biological processes enriched for both up and down regulated genes between parous and nulliparous breast samples

GO:0007044

cell-substrate junction assembly (0.006)

KRT5, LAMA3, LAMC2

GO:0007398

ectoderm development (0.002)

COL7A1, KRT5, KRT15, LAMA3, LAMC2, NTF4, KLK7

GO:0008544

epidermis development (0.001)

COL7A1, KRT5, KRT15, LAMA3, LAMC2, NTF4, KLK7

GO:0010160

formation of organ boundary(0.009)

NTF4

GO:0031581

hemidesmosome assembly (0.000)

KRT5, LAMA3, LAMC2

GO:0016071

mRNA metabolic process (0.000)

CIRBP, RBMX, HNRNPA1, HNRNPA2B1, HNRNPD, LUC7L3, PNN, PRPF39, RBM25, SFPQ, SFRS1, SFRS5, SFRS7, PABPN1, PRPF4B

GO:0006397

mRNA processing (0.000)

RBMX, HNRNPA1, HNRNPA2B1, LUC7L3, PNN, PRPF39, RBM25, SFPQ, SFRS1, SFRS5, SFRS7, PABPN1, PRPF4B

GO:0034059

response to anoxia (0.009)

OXTR

GO:0016070

RNA metabolic process (0.006)

DDX17, CHD2,C BX3, CIRBP, ZNF785, EZH2, L3MBTL, GATA3, RBMX, ZNF789, HNRNPA1, HNRNPA2B1, HNRNPD, LUC7L3, PNN, PRPF39, ZNF83, METTL3, CREBZF, RBM25, RBBP8, RPS24, CENPK, SFPQ, SFRS1, SFRS5, SFRS7, ZNF814, ZNF207, PABPN1, RUNX3, FUBP1, PRPF4B, HNRPDL

GO:0006396

RNA processing (0.000)

DDX17, RBMX, HNRNPA1, HNRNPA2B1, HNRNPD, LUC7L3, PNN, PRPF39, RBM25, RPS24, SFPQ, SFRS1, SFRS5, SFRS7, PABPN1, PRPF4B, HNRPDL

GO:0008380

RNA splicing (0.000)

RBMX, HNRNPA1, HNRNPA2B1, HNRNPD, LUC7L3, PNN, PRPF39, RBM25, SFPQ, SFRS1, SFRS5, SFRS7, PABPN1, PRPF4B

GO term ID

GO term

Genes down-regulated in parous samples

GO:0032859

activation of Ral GTPase activity (0.003)

RALGAPA2

GO:0021534

cell proliferation in hindbrain (0.005)

IGF1

GO:0009441

glycolate metabolic process (0.001)

IGF1

GO:0042692

muscle cell differentiation (0.006)

IGF1, SOX6

GO:0051450

myoblast proliferation (0.003)

IGF1

GO:0006654

phosphatidic acid biosynthetic process (0.005)

ABHD5

GO:0031325

positive regulation of cellular metabolic process (0.005)

EBF1, IGF1, ABHD5, SOX6

GO:0045821

positive regulation of glycolysis (0.006)

IGF1

GO:0051006

positive regulation of lipoprotein lipase activity (0.006)

ABHD5

GO:0042523

positive regulation of tyrosine phosphorylation of Stat5 protein (0.009)

IGF1

GO:0031329

regulation of cellular catabolic process (0.002)

IGF1, ABHD5

GO:0043567

regulation of insulin-like growth factor receptor signaling pathway (0.007)

IGF1

GO:0010660

regulation of muscle cell apoptosis (0.006)

IGF1

GO:0032485

regulation of Ral protein signal transduction (0.003)

RALGAPA2

GO:0010889

regulation of sequestering of triglyceride (0.006)

ABHD5

GO:0033143

regulation of steroid hormone receptor signaling pathway (0.010)

IGF1

GO:0090207

regulation of triglyceride metabolic process (0.008)

ABHD5

GO:0043403

skeletal muscle tissue regeneration (0.009)

IGF1

GO:0007264

small GTPase mediated signal transduction (0.005)

IGF1, RASD1, RALGAPA2

GO:0035019

somatic stem cell maintenance (0.010)

IGF1