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Table 2 Amplicons and p53 alterations according to array CGH clusters and G2I classes of tumors (%)

From: An array CGH based genomic instability index (G2I) is predictive of clinical outcome in breast cancer and reveals a subset of tumors without lymph node involvement but with poor prognosis

  All Array CGH clusters G2I classes
   a b c d e f 1 2 3
Total tumors 135 34 25 16 13 35 12 19 88 28
Tumors with amplicons 64 (47) 14 (41) 8 (32) 10 (63) 7 (54) 17 (49) 8 (67) 3 (16) 41 (47) 20 (71)
Amplicons 296 60 43 37 24 69 63 6 173 117
Amplicons per tumor (mean) 2.2 1.8 1.7 2.3 1.8 2.0 5.3 0.3 2.0 4.2
Amplicons per tumor in tumors with amplicons (mean) 4.6 4.3 5.4 3.7 3.4 4.1 7.9 2 4.2 5.9
5q23.3 (a) 7 (5) 2 ( 6) 3 (12) 0 0 2 ( 6) 0 0 5 (6) 2 (7)
8p12a or 8p12-p11 11 (8) 2 (6) 1 (4) 2 (8) 3 (23) 2 ( 6) 1 (8) 0 8 (9) 3 (11)
11q13.2-q13.3 18 (13) 4 (12) 1 (4) 2 (8) 0 8 (23) 3 (25) 1 (5) 9 (10) 8 (29)
11q14.1a 11 (8) 3 (9) 0 2 (13) 0 5 (14) 1 (8) 1 (5) 7 (8) 3 (11)
12q13.11-q13.12 7 (5) 1 (3) 1 (4) 0 0 3 (9) 2 (17) 0 4 (5) 3 (11)
17q11.2b 6 (4) 1 (3) 1 (4) 0 0 2 (6) 2 (17) 0 3 (3) 3 (11)
17q12e 17 (3) 4 (12) 3 (12) 1 (4) 4 (31) 4 (11) 1 (8) 1 (5) 12 (14) 4 (14)
17q21.1-q21.2 8 (6) 2 (6) 2 (8) 0 2 (15) 2 (6) 0 1 (5) 5 (6) 2 (7)
17q21.31 8 (6) 1 (3) 0 1 (6) 2 (15) 3 (9) 1 (8) 1 (5) 5 (6) 2 (7)
17q21.33 8 (6) 1 (3) 0 1 (6) 2 (15) 2 (6) 2 (7) 0 4 (5) 4 (14)
20q (b) 11 (8) 3 (9) 1 (4) 0 0 3 (9) 4 (33) 0 5 (6) 6 (21)
p53 alteration (c) 39 (29) 11 (32) 5 (17) 5 (31) 4 (31) 7 (20) 7 (58) 0 24 (27) 15 (54)
  1. a) number of tumors (%) with the 11 most recurrent amplicons described in Additional file 2 b) tumors with at least one amplicon on 20q: at 20q11.21 , 20q13.2 or 20q13.31-q32; c) TP53 mutation or immunohistochemistry p53 accumulation.