Table 5 Association between G2I classes and clinico-pathological parameters
Clinicopathological Parameters | Total n = 135 (%) | G2I-1 19 | G2I-2 88 | G2I-3 28 | χ2 test p-value |
|---|---|---|---|---|---|
Lymph node involvement | |||||
pN0 | 75 (56) | 12 (63) | 43 (49) | 20 (83) | 0.086 |
pN+ | 60 (44) | 7 (37) | 45 (51) | 8 (29) | |
Age (years) | |||||
<=55 | 70 (52) | 8 (42) | 51 (58) | 11 (39) | 0.149 |
>55 | 65 (48) | 11 (58) | 37 (42) | 17 (61) | |
Histological size (mm) | |||||
<= 20 | 90 (67) | 16 (84) | 57 (65) | 17 (61) | 0.2 |
> 20 | 45 (33) | 3 (16) | 31 (35) | 11 (39) | |
Scarff Bloom Richardson (SBR) Grade | |||||
1 | 25 (18) | 6 (32) | 15 (17) | 4 (14) | 0.037 |
2 | 71 (53) | 12 (63) | 48 (55) | 11 (39) | |
3 | 39 (29) | 1 ( 5) | 25 (28) | 13 (39) | |
Steroid Hormone Receptor status | |||||
HR+ : > = 10% | 116 (86) | 18 (95) | 74 (84) | 24 (86) | 0.48 |
HR- | 19 (14) | 1 ( 5) | 14 (16) | 4 (14) | |
Nottingham prognostic index (NPI) | |||||
1 + 2 | 30 (22) | 6 (32) | 20 (23) | 4 (14) | 0.37 |
3 | 85 (63) | 13 (68) | 50 (57) | 22 (79) | |
4 | 20 (15) | 0 ( 0) | 18 (20) | 2 ( 7) | |
Mib1 | |||||
<20% | 93 (69) | 18 (95) | 60 (68) | 15 (54) | 0.011 |
≥20% | 42 (31) | 1 ( 5) | 28 (32) | 13 (46) | |
Ihc intrinsic classification(a) | |||||
LA | 83 (62) | 16 (84) | 55 (64) | 12 (43) | 0.014 |
LB + her2+ Basal | 50 (38) | 3 (16) | 31 (36) | 16 (57) | |
unclassified | 2 | 0 | 2 | 0 | |
p53 status (b) | |||||
- | 95 (71) | 19 (100) | 64 (73) | 13 (46) | 0.0003 |
+ | 39 (29) | 0 ( 0) | 24 (27) | 15 (54) | |
At least one amplicon | |||||
No | 71 (53) | 16 (84) | 47 (53) | 8 (29) | 0.001 |
Yes | 64 (47) | 3 (16) | 41 (47) | 20 (71) | |