Routine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples

Table 1 Characteristics of the patients.

Covariates	Overall	APLs	t(8;21)-AMLs	inv(16)-AMLs	NK-AMLs
Patients	N = 97	N = 18	N = 19	N = 29	N = 31
Gender
Males	44	7	13	15	9
Females	53	11	6	14	22
Age at diagnosis
Median (years)	54	56	53	38	60
Range	18-87	19-87	18-84	18-70	25-78
Leukocytosis at diagnosis
WBC ≥ 30 G/L	39	2	6	12	19
FAB classification
M1 or M2	45	0	18	6	21
M3	18	18	0	0	0
M4 or M5	34	0	0	24	10
Cytogenetics
Expected anomaly*	62	16	19	27	0
Normal karyotype	34	2	0	1	31
Karyotype failure	1	0	0	1	0
Gene mutations
FLT3-ITD^$	19	2	1	2	14
FLT3-D835^&	7	2	2	2	1
NPM1	18	0	0	1	17
CEBPA (mono-allelic)	4	0	2	1	1

WBC, white blood cells. * t(15;17), t(8;21), inv(16) or t(16;16) for APL, t(8;21)-AML and inv(16)-AML, respectively detected. ^$ Internal tandem duplication. ^&Mutation Asp835 of the tyrosine kinase domain.

ISSN: 1755-8794