Table 5 Genotype frequencies of each SNP in COPD and control subjects for SNPs

rs1059823

GG

24(11)

39(11)

0.8120

0.93

0.52-1.67

61.7120

GA+AA

187(89)

292(89)

GG+GA

115(55)

183(55)

0.8760

0.97

0.68-1.39

66.5760

AA

96(45)

148(45)

rs17019336

AA

26(12)

35(11)

0.0100

0.14

0.09-0.22

0.7600

TA+TT

184(88)

294(89)

AA+AT

110(52)

207(63)

0.0210

1.54

1.07-2.21

1.5960

TT

100(48)

122(37)

rs1799964

TT

130(62)

206(63)

0.8010

0.95

0.66-1.38

60.8760

TC+CC

80(38)

121(37)

TT+TC

203(97)

313(96)

0.9180

0.96

0.41-2.23

69.7680

CC

7(3)

14(4)

rs1800610

TT

9(4)

13(4)

0.9940

1.00

0.41-2.44

75.5440

TC+CC

204(96)

318(96)

TT+TC

62(29)

99(30)

0.7350

1.07

0.72-1.59

55.8600

CC

151(71)

232(70)

rs2077464

TT

85(40)

138(43)

0.6620

1.09

0.75-1.57

50.3120

TC+CC

125(60)

181(57)

TT+TC

186(89)

282(88)

0.8190

0.94

0.53-1.64

62.2440

CC

24(11)

37(12)

rs2236302

CC+GC

208(99)

327(99)

0.8210

1.26

0.18-8.99

62.3960

GG

2(1)

2(1)

CC

161(77)

257(78)

0.4060

1.20

0.78-1.84

30.8560

GG+GC

49(23)

72(22)

rs2292566

AA

21(10)

36(11)

0.7410

1.11

0.61-2.0

56.3160

GG+AG

189(90)

293(89)

AA+AG

106(50)

156(47)

0.8610

1.03

0.72-1.48

65.4360

GG

rs2353397

CC

19(9)

121(37)

0.4850

1.24

0.68-2.28

36.8600

CT+TT

191(91)

210(63)

CC+CT

104(50)

261(79)

0.3740

1.18

0.82-1.69

28.4240

TT

106(50)

70(21)

rs25882

TT

30(14)

46(14)

0.9400

1.02

0.61-1.71

71.4400

CT+CC

180(86)

283(86)

TT+CT

117(56)

194(59)

0.3490

1.19

0.83-1.72

26.5240

CC

93(44)

135(41)

rs2808630

CC

4(2)

10(3)

0.4820

0.90

0.66-1.22

36.6320

CT+TT

206(98)

319(97)

CC+CT

62(30)

109(33)

0.2200

0.80

0.55-1.15

16.7200

TT

148(70)

220(67)

rs3749893

AA

100(47)

161(50)

0.4510

1.11

0.85-1.46

34.2760

AG+GG

113(53)

166(50)

AA+AG

186(87)

293(90)

0.6830

1.08

0.75-1.55

51.9080

GG

27(13)

34(10)

rs4987835

AA

65(31)

121(38)

0.2280

1.27

0.86-1.86

17.3280

AG+GG

145(69)

196(62)

AA+AG

171(81)

261(80)

0.6900

1.10

0.69-1.76

52.4400

GG

39(19)

56(20)

rs709932

AA

8(4)

16(5)

0.7950

1.13

0.45-2.84

60.4200

AG+GG

202(96)

309(95)

AG+AA

65(31)

115(35)

0.2570

1.25

0.85-1.82

19.5320

GG

145(69)

210(65)

rs7217852

AA

86(41)

141(43)

0.6180

1.01

0.76-1.58

46.9680

AG+GG

124(59)

189(57)

AA+AG

187(89)

293(89)

0.7000

0.89

0.51-1.57

53.2000

GG

23(11)

37(11)

rs7776375

AA

83(39)

148(45)

0.0900

1.37

0.95-1.98

6.8400

AG+GG

130(61)

183(55)

AA+AG

187(39)

290(45)

0.7940

0.93

0.54-1.6

60.3440

GG

26(12)

41(12)

rs10069690

TT

12(6)

7(2)

0.7100

0.93

0.64-1.35

53.9600

CT+CC

194(94)

315(98)

TT+CT

69(33)

117(36)

0.0240

3.14

1.17-9.92

1.8240

CC

137(67)

205(64)

rs1051740

TT

72(35)

123(37)

0.5730

1.12

0.76-1.63

43.5480

TC+CC

133(65)

208(63)

TT+TC

175(85)

280(85)

0.6070

0.88

0.53-1.45

46.1320

CC

30(15)

51(15)

rs11155242

AA

169(82)

276(83)

0.3060

1.27

0.80-2.01

23.2560

AC+CC

38(18)

55(17)

AA+AC

203(98)

328(99)

0.5030

1.68

0.37-7.56

38.2280

CC

4(2)

3(1)

rs1295685

TT

19(9)

37(12)

0.4470

1.27

0.69-2.32

33.9720

TC+CC

188(91)

294(88)

TT+CT

99(48)

184(56)

0.1880

1.27

0.89-1.83

14.2880

CC

108(52)

147(44)

rs1435867

CC

5(2)

7(2)

0.7660

0.83

0.24-2.85

58.2160

CT+TT

200(98)

321(98)

CC+CT

50(24)

83(25)

0.5380

0.88

0.58-1.33

40.8880

TT

155(76)

245(75)

rs16909898

GG

2(1)

1(0.3)

0.4560

0.40

0.03-4.45

34.6560

GA+AA

204(99)

329(99.7)

GG+GA

31(15)

53(16)

0.3580

0.80

0.49-1.30

27.2080

AA

175(85)

277(84)

rs1881457

AA

117(56)

187(56)

0.9540

0.99

0.69-1.42

72.5040

AC+CC

91(44)

144(44)

AA+AC

191(92)

308(93)

0.7340

1.13

0.57-2.22

55.7840

CC

17(8)

23(7)

rs2241718

TT

10(5)

26(8)

0.1380

1.80

0.83-3.88

10.4880

TC+CC

196(95)

305(92)

TT+TC

104(50)

180(54)

0.5480

1.12

0.78-1.60

41.6480

CC

102(50)

151(46)

rs2277027

CC

5(2)

10(3)

0.4990

1.47

0.49-4.44

37.9240

CA+AA

202(98)

321(97)

CC+CA

59(29)

96(29)

0.6170

0.90

0.61-1.34

46.8920

AA

148(71)

235(71)

rs2736100

TT

72(36)

108(34)

0.7840

0.95

0.65-1.39

59.5840

TG+GG

130(64)

207(66)

TT+TG

159(79)

260(83)

0.2490

1.32

0.83-2.10

18.9240

GG

43(21)

55(17)

rs35621

CC

114(56)

185(56)

0.3820

1.18

0.82-1.69

29.0320

CT+TT

91(44)

146(44)

CC+CT

191(93)

314(95)

0.5710

1.25

0.58-2.67

43.3960

TT

14(7)

17(5)

rs3995090

CC

98(48)

163(50)

0.2110

1.26

0.88-1.80

16.0360

CA+AA

107(52)

160(50)

CC+CA

190(93)

298(92)

0.6630

0.86

0.43-1.70

50.3880

AA

15(7)

25(8)

rs4246742

AA

71(35)

136(41)

0.0550

1.44

0.99-2.10

4.1800

AT+TT

134(65)

195(59)

AA+AT

173(84)

293(89)

0.1700

1.44

0.86-2.42

12.9200

TT

32(16)

38(11)

rs6712954

GG

128(62)

218(66)

0.1940

1.28

0.88-1.86

14.7440

GA+AA

78(38)

113(34)

GG+GA

193(94)

327(99)

0.0130

4.25

1.37-13.24

0.9880

AA

13(6)

4(1)

rs829259

AA

24(12)

35(11)

0.4770

0.81

0.45-1.46

36.2520

AT+TT

182(88)

296(89)

AA+AT

113(55)

198(60)

0.5920

1.11

0.77-1.59

44.9920

TT

93(45)

133(40)

rs10075508

TT

4(2)

6(2)

0.3660

0.49

0.10-2.30

27.8160

TC+CC

209(98)

320(98)

TT+TC

65(31)

102(31)

0.7280

1.07

0.73-1.58

55.3280

CC

148(69)

224(69)

rs10512249

TT

2(1)

1(0.3)

0.4560

0.40

0.04-4.45

34.6560

TC+CC

206(99)

310(99.7)

TT+TC

31(15)

51(16)

0.4150

1.27

0.71-2.27

31.5400

CC

177(85)

260(84)

rs12899618

GG

162(78)

259(79)

0.3010

1.26

0.82-1.94

22.8760

GA+AA

47(32)

66(21)

GG+GA

208(99)

320(98)

0.1430

0.20

0.02-1.71

10.8680

AA

1(1)

5(2)

rs13706

GG

85(40)

138(42)

0.7230

1.07

0.74-1.54

54.9480

GA+AA

125(60)

188(58)

GG+GA

187(89)

289(89)

0.3210

0.76

0.43-1.31

24.3960

AA

23(11)

37(11)

rs1531697

AA

75(36)

134(41)

0.2920

1.22

0.84-1.77

22.1920

AT+TT

134(64)

191(59)

AA+AT

180(86)

277(85)

0.9290

0.98

0.58-1.645

70.6040

TT

29(14)

48(15)

rs1800925

TT

6(3)

12(4)

0.7160

1.22

0.43-3.47

54.4160

TC+CC

201(97)

294(96)

TT+TC

56(27)

93(31)

0.0790

1.41

0.96-2.08

6.0040

CC

151(73)

213(69)

rs3024791

GG

181(87)

293(90)

0.3770

1.27

0.75-2.14

28.6520

GA+AA

27(13)

31(10)

GG+GA

207(99.5)

323(99.7)

0.8760

1.25

0.08-20.07

66.5760

AA

1(0.5)

1(0.3)

rs6537302

AA

115(55)

194(62)

0.5150

1.13

0.79-1.62

39.1400

AT+TT

92(45)

117(38)

AA+AT

195(94)

286(92)

0.3070

0.68

0.33-1.41

23.3320

TT

12(6)

25(8)

rs6555465

GG

40(19)

83(26)

0.1920

1.34

0.86-2.10

14.5920

GA+AA

173(81)

241(74)

GG+GA

155(73)

227(70)

0.8710

0.97

0.65-1.45

66.1960

AA

58(27)

97(30)

rs673400

CC

0(0)

0(0)

NA

NA

NA

NA

CG+GG

208(100)

323(100)

CC+CG

178(86)

278(86)

0.8190

0.94

0.56-1.57

62.2440

GG

30(14)

45(14)

rs6889822

GG

84(40)

133(42)

0.4800

1.14

0.79-1.65

36.4800

GA+AA

124(60)

187(58)

GG+GA

184(88)

284(89)

0.7550

1.10

0.62-1.95

57.3800

AA

24(12)

36(11)

rs8004738

GG

45(22)

68(22)

0.7910

1.06

0.69-1.64

60.1160

GA+AA

163(78)

245(78)

GG+GA

139(67)

207(66)

0.6880

1.08

0.74-1.60

52.2880

AA

69(33)

106(34)

rs1003349

GG

68(33)

122(37)

0.1880

1.29

0.88-1.89

14.2880

GT+TT

140(67)

204(63)

GG+GT

170(82)

270(83)

0.6130

1.13

0.70-1.83

46.5880

TT

38(18)

56(17)

rs1032295

TT

119(56)

206(63)

0.1570

1.30

0.90-1.88

11.9320

TG+GG

94(44)

122(37)

TT+TG

201(94)

317(97)

0.2380

1.70

0.70-4.12

18.0880

GG

12(6)

11(3)

rs1042522

CC

37(18)

60(18)

0.8050

1.06

0.66-1.70

61.1800

GC+GG

173(82)

266(82)

CC+CG

147(70)

244(75)

0.2860

1.25

0.83-1.86

21.7360

GG

63(30)

82(25)

rs1052443

CC

96(46)

163(50)

0.2950

1.21

0.85-1.74

22.4200

CA+AA

114(54)

160(50)

CC+CA

185(88)

294(91)

0.1970

1.49

0.81-2.71

14.9720

AA

25(12)

29(9)

rs12504628

TT

107(50)

166(50)

0.9000

0.98

0.68-1.40

68.4000

TC+CC

106(50)

162(50)

TT+TC

198(93)

309(94)

0.7810

1.11

0.54-2.27

59.3560

CC

15(7)

19(6)

rs1695

GG

5(2)

10(3)

0.4990

1.47

0.48-4.44

37.9240

GA+AA

204(98)

318(97)

GG+GA

67(32)

116(35)

0.5520

1.12

0.77-1.64

41.9520

AA

142(68)

212(65)

rs1800469

CC

39(19)

74(23)

0.9960

1.34

0.98-1.95

75.6960

TC+TT

169(81)

252(77)

CC+TC

143(69)

241(74)

0.2530

1.26

0.85-1.88

19.2280

TT

65(31)

85(26)

rs2853209

AA

42(20)

68(21)

0.4560

1.18

0.76-1.84

34.6560

AT+TT

169(80)

251(79)

AA+AT

149(71)

232(72)

0.4850

0.87

0.59-1.28

36.8600

TT

62(29)

92(28)

rs4073

AA

36(17)

68(21)

0.2460

1.32

0.83-2.09

18.6960

AT+TT

174(83)

256(79)

AA+AT

149(71)

232(72)

0.3260

1.22

0.82-1.83

24.7760

TT

61(29)

92(28)

rs6937121

TT

72(34)

141(43)

0.0280

1.52

1.05-2.20

2.1280

TG+GG

138(66)

185(57)

TT+TG

182(87)

282(86)

0.6680

0.89

0.53-1.50

50.7680

GG

28(13)

44(14)

rs6957

GG

21(10)

40(12)

0.2810

1.37

0.77-2.43

21.3560

GA+AA

188(90)

288(88)

GG+GA

129(62)

201(61)

0.8730

0.97

0.67-1.41

66.3480

AA

80(38)

127(39)

rs1051730

CC

196(95)

311(94)

0.5330

1.25

0.62-2.50

40.5080

CT+TT

11(5)

20(6)

CC+CT

207(100)

330(99.7)

NA

NA

NA

NA

TT

0(0)

1(0.3)

rs11106030

CC

153(73)

237(72)

0.9350

1.02

0.68-1.52

71.0600

CA+AA

56(27)

93(28)

CC+CA

202(96)

323(98)

0.3350

1.77

0.55-5.66

25.4600

AA

7(4)

7(2)

rs1130864

TT

0(0)

0(0)

NA

NA

NA

NA

TC+CC

206(100)

317(100)

TT+TC

23(11)

43(14)

0.3720

1.26

0.76-2.07

28.2720

CC

183(89)

274(86)

rs2241712

AA

44(21)

92(28)

0.1560

1.37

0.89-2.10

11.8560

AG+GG

163(79)

239(72)

AA+AG

144(69)

250(76)

0.2290

1.28

0.86-1.92

17.4040

GG

63(31)

81(24)

rs2280090

GG

185(88)

299(90)

0.4650

1.23

0.71-2.14

35.3400

GA+AA

26(12)

32(10)

GG+GA

210(99.5)

330(99.4)

0.8760

1.25

0.08-20.07

66.5760

AA

1(0.5)

1(0.6)

rs2395730

AA

20(9)

48(15)

0.0490

1.77

1.00-3.13

3.7240

AC+CC

191(91)

283(85)

AA+AC

99(9)

161(49)

0.3610

1.18

0.82-1.70

27.4360

CC

112(53)

170(51)

rs2736118

AA

186(88)

299(90)

0.2740

1.38

0.78-2.45

20.8240

AG+GG

25(12)

32(10)

AA+AG

211(100)

331(100)

NA

NA

NA

NA

GG

0(0)

0(0)

rs2736122

CC

181(87)

301(90)

0.035

1.84

1.04-3.24

2.6600

CT+TT

26(13)

30(10)

CC+CT

181(100)

331(100)

NA

NA

NA

NA

TT

0(0)

0(0)

rs3817928

AA

166(81)

268(81)

0.4490

1.19

0.76-1.85

34.1240

AG+GG

41(19)

63(19)

AA+AG

204(99)

328(99)

0.7860

1.25

0.25-6.26

59.7360

GG

3(1)

3(1)

rs584367

TT

10(5)

14(4)

0.5010

0.73

0.30-1.82

38.0760

TC+CC

197(95)

317(96)

TT+TC

81(39)

138(42)

0.6410

1.10

0.76-1.57

48.7160

CC

126(61)

193(58)

rs1042714

CC

168(81)

280(85)

0.1020

1.48

0.93-2.36

7.7520

GC+GG

39(19)

49(15)

CC+GC

206(99)

327(99)

0.6990

0.62

0.06-6.90

53.1240

GG

1(1)

2(1)

rs13147758

AA

102(50)

168(52)

0.6310

1.09

0.76-1.57

47.9560

AG+GG

104(50)

157(48)

AA+AG

181(88)

296(91)

0.2920

1.38

0.76-2.49

22.1920

GG

25(12)

29(9)

rs1422795

GG

5(2)

11(3)

0.4990

1.47

0.48-4.44

37.9240

GA+AA

202(98)

313(97)

GG+GA

56(27)

97(29)

0.9400

0.99

0.66-1.46

71.4400

AA

151(73)

232(71)

rs1800796

CC

110(53)

168(51)

0.5080

0.89

0.62-1.27

38.6080

CG+GG

97(47)

161(49)

CC+CG

183(88)

305(97)

0.1060

1.68

0.90-3.16

8.0560

GG

24(12)

24(3)

rs2236307

CC

41(20)

62(19)

0.9460

0.98

0.62-1.55

71.8960

CT+TT

166(80)

267(81)

CC+CT

128(62)

224(68)

0.2150

1.27

0.87-1.86

16.3400

TT

79(38)

105(32)

rs2280091

AA

178(86)

283(86)

0.6730

1.11

0.68-1.82

51.1480

AG+GG

29(14)

45(14)

AA+AG

205(99)

328(100)

NA

NA

NA

NA

GG

2(1)

0(0)

rs2853676

GG

137(67)

225(69)

0.3510

1.20

0.82-1.75

26.6760

GA+AA

69(33)

103(31)

GG+GA

198(97)

319(98)

0.3930

1.58

0.56-4.46

29.8680

AA

8(3)

9(2)

rs868966

AA

56(27)

84(26)

0.6620

0.91

0.60-1.38

50.3120

AG+GG

151(73)

245(74)

AA+AG

149(72)

253(77)

0.3970

1.20

0.79-1.80

30.1720

GG

58(28)

76(23)