| | |
Genotypes cases
| |
Genotypes controls
| | | | |
---|
Position
|
rs-Number
|
Amino acid exchange
|
11
|
12
|
22
|
Minor allele frequency cases [%]
|
11
|
12
|
22
|
Minor allele frequency controls [%]
|
Odds Ratiod
|
95% Confidence Interval
|
Nominal p-value
|
---|
g.2749C/A
|
rs147094247
|
Thr175Asp
|
11, 257
|
11
|
0
|
0.05
|
4,511
|
1
|
0
|
0.01
|
4.4
|
0.57 - 34.13
|
0.199c
|
g.8164A/G
|
rs7498665
|
Thr484Ala
|
512
|
1,526
|
1,101
|
40.62
|
58
|
195
|
181
|
35.83
|
1.2
|
1.06-1.42
|
0.007
a
|
g.8250C/T
|
rs60604881
| |
70
|
87
|
22
|
36.59
|
73
|
75
|
37
|
40.27
|
0.86
|
0.63 - 1.15
|
0.323b
|
g.8738A/G
|
rs62037368
| |
176
|
2
|
0
|
0.56
|
182
|
3
|
0
|
0.81
|
0.69
|
0.11 - 4.16
|
1b
|
g.8764C/T
|
rs62037369
| |
65
|
81
|
32
|
40.73
|
79
|
82
|
23
|
34.78
|
1.29
|
0.95 - 1.74
|
0.107b
|
g.9483C/T
| |
βThr656Ile, γPro674Ser
|
11,206
|
2
|
0
|
0.01
|
4,506
|
0
|
0
|
0.00
|
NA
|
NA
|
1c
|
g.10182C/A
| | |
178
|
1
|
0
|
0.28
|
184
|
0
|
0
|
0.00
|
NA
|
NA
|
0.493b
|
-
a genotyped in 3,230 obese cases and 439 lean controls.
-
b genotyped in a total of 179 obese cases and 185 lean controls.
-
c genotyped in a total of 11,406 obese and overweight cases and 4,568 (mainly population based) controls.
-
d Odds ratio is given with respect to the minor allele.