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Table 1 Frequencies of LOH, LOI and MOI in human ovarian cancers.

From: High-throughput detection of aberrant imprint methylation in the ovarian cancer by the bisulphite PCR-Luminex method

(A) Ovarian cancer tissues
  H19/
R sal
IGF2/
Apal
KCNQ1/
Smal
LIT1/
R sal
GTL2/
T aal
PEG1/
AFlll
PEG3/
Mnll
NDN/
Mbol
Heterozygosity 58.5
(41/70)
47.1
(33/70)
55.5
(40/72)
16.2
(12/74)
58.3
(42/72)
50.0
(37/74)
34.2
(25/73)
41.8
(31/74)
LOH 4.8
(2/41)
9.0
(3/33)
5.0
(2/40)
0.0
(0/12)
7.1
(3/42)
8.1
(3/37)
4.0
(1/25)
0.0
(0/31)
LOI 29.2
(12/41)
45.4
(15/33)
12.5
(5/40)
16.6
(2/12)
23.8
(10/42)
45.9
(17/37)
8.0
(2/25)
6.4
(2/31)
MOI 56.0
(23/41)
33.3
(11/33)
77.5
(31/40)
83.3
(10/12)
66.6
(28/42)
45.9
(17/37)
84.0
(21/25)
93.5
(29/31)
ND 9.7
(4/41)
12.1
(4/33)
5.0
(2/40)
0.0
(0/12)
2.3
(1/42)
0.0
(0/37)
4.0
(1/25)
0.0
(0/31)
(B) Cell lines
Heterozygosity 19.0
(4/21)
14.2
(3/21)
33.3
(7/21)
14.39
(3/21)
23.8
(5/21)
42.8
(9/21)
23.8
(5/21)
23.8
(5/21)
LOI 0/4 2/3 3/7 1/3 2/5 3/9 0/5 0/5
MOI 4/4 1/3 4/7 2/3 3/5 6/9 5/5 5/5
  1. Percents of LOH (loss of heterozygosity), LOI (loss of imprinting) and MOI (maintenance of methylation) determined using RFLP analysis of 8 imprinted genes in 74 samples of ovarian cancers and 21 cell lines