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Table 3 Characterization of methylation profiles of the imprinted genes in DNA of ovarian cancers.

From: High-throughput detection of aberrant imprint methylation in the ovarian cancer by the bisulphite PCR-Luminex method

(A) Histology
   H19 GTL2 ZDBF2 PEG1 LIT1 ZAC PEG3 SNRPN
Normal (n = 7) 34.3 ± 11.8 34.7 ± 9.5 44.2 ± 6.6 30.7 ± 15.1 27.9 ± 12.6 33.1 ± 5.8 42.8 ± 18.5 44.9 ± 25.3
Cancer (n = 74) 41.7 ± 17.2 39.6 ± 18.8 43.8 ± 6.6 45.9 ± 15.5* 27.9 ± 14.1 41.1 ± 6.4 41.1 ± 14.1 42.8 ± 12.9
   Serous (n = 36) 47.6 ± 18.9 38.8 ± 22.0 42.0 ± 18.5 48.9 ± 14.7* 28.8 ± 9.8 42.7 ± 16.6 40.9 ± 14.8 39.3 ± 12.2
   Mucinous (n = 9) 36.0 ± 15.0 35.2 ± 19.2 36.8 ± 14.0 47.1 ± 20.0 34.7 ± 21.4 42.2 ± 5.9 31.2 ± 11.2 42.7 ± 17.8
   Endometrioid (n = 10) 37.9 ± 14.8 30.7 ± 14.4** 57.8 ± 19.8 45.5 ± 13.7 22.8 ± 13.0 37.5 ± 11.5 46.8 ± 15.9 41.4 ± 10.8
   Clear (n = 18) 45.6 ± 20.2 54.0 ± 20.1 39.7 ± 20.8 42.2 ± 13.8 25.5 ± 12.4 40.2 ± 16.1 45.7 ± 14.5 47.8 ± 11.1
(B) Progress (Staging)
Localized (I, II) (n = 29) 38.8 ± 14.9 40.8 ± 20.4 46.7 ± 19.4 47.8 ± 17.1 30.4 ± 16.1 41.0 ± 11.9 42.8 ± 17.8 44.2 ± 12.9
Advanced (III, IV) (n = 45) 47.8 ± 19.6 41.3 ± 22.2 41.9 ± 19.2 45.9 ± 13.7 26.2 ± 10.0 41.1 ± 16.8 41.2 ± 12.8 40.9 ± 12.6
(C) Age
Under 44 years (n = 17) 46.7 ± 18.5 35.3 ± 21.0 42.0 ± 20.4 48.9 ± 13.5 24.2 ± 11.7 39.9 ± 12.3 44.7 ± 14.3 36.3 ± 10.7
45-55 years (n = 29) 39.9 ± 14.7 47.2 ± 23.0 45.8 ± 17.5 46.9 ± 15.0 30.1 ± 14.8 38.9 ± 15.5 41.9 ± 15.8 45.4 ± 11.1
Over 56 years (n = 32) 47.4 ± 21.2 38.4 ± 18.1 42.2 ± 21.1 45.1 ± 16.2 28.2 ± 10.9 44.1 ± 15.7 40.8 ± 14.9 42.5 ± 14.5
  1. The values in the list are mean ± SD (standard deviation). Statistically significant differences between groups are presented as *P < 0.05, and **P < 0.01 by ANOVA