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Figure 6 | BMC Medical Genomics

Figure 6

From: Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C

Figure 6

Sex-specific DNA methylation differences in FBXL5, CACYBP and SCMH1 promoters in blood and four brain regions. Boxplots show DNA methylation levels in three CpGs located in the promoters of FBXL5, CACYBP and SCMH1 in 99 (48 males/51 females) blood samples (GSE20067), 133 (90 males/43 females) frontal cortex samples (FCTX), 127 (85 males/42 females) temporal cortex samples (TCTX), 121 (86 males/35 females) cerebellum samples (CBL) and 125 (87 males/38 females) pons samples from neurologically normal individuals (GSE15745). The Y axis shows DNA methylation levels presented as C/C + T and ranging from 0 to 1. The bottom and the top of the box are 25th and 75th percentiles respectively, the whiskers are within the 1.5 interquartile range (IQR) of the data, and the circles, are outlier data points above or below 1.5 IQR. P-values were calculated using Kruskal-Wallis test. **** is p <0.0001, *** is p < 0.001, ** is p < 0.01, * is p < 0.05, NS is p > 0.1.

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