Table 3 Principal gene pathways altered in uremia

Transport: Clathrin-coated vesicle cycle

8.039E-23

60 /

71

Cytoskeleton remodeling: TGF, WNT and cytoskeletal remodeling

2.990E-19

77 /

111

Cytoskeleton remodeling: Cytoskeleton remodeling

3.226E-17

70 /

102

Development: EPO-induced Jak-STAT pathway

2.658E-16

33 /

35

Translation: Regulation of EIF4F activity

2.083E-15

43 /

53

Chemotaxis: CXCR4 signaling pathway

2.445E-14

31 /

34

Development: GM-CSF signaling

4.953E-14

40 /

50

Immune response: T cell receptor signaling pathway

5.938E-14

41 /

52

Immune response: IL-2 activation and signaling pathway

1.410E-13

39 /

49

Oxidative phosphorylation

1.787E-13

66 /

105

Immune response : Immunological synapse formation

2.407E-13

44 /

59

Development: Flt3 signaling

2.595E-13

36 /

44

Signal transduction: Activation of PKC via G-Protein coupled receptor

5.244E-13

40 /

52

Cell cycle: Influence of Ras and Rho proteins on G1/S Transition

1.552E-12

40 /

53

Immune response: Role of DAP12 receptors in NK cells

4.346E-12

40 /

54

Immune response: BCR pathway

4.346E-12

40 /

54

Transcription: NF-kB signaling pathway

4.945E-12

32 /

39

Development: PIP3 signaling in cardiac myocytes

9.777E-12

36 /

47

Development: EGFR signaling pathway

1.026E-11

44 /

63