Figure 2From: Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome Western blot analysis of total ubiquitin-bound protein levels. A) Western blot performed on lymphoblasts and fetal fibroblasts in basal conditions and following proteasome blocking (40 μM MG132 for six hours). B) Histograms show the average protein ubiquitination of lymphoblasts derived from two controls and two DS subjects, normalized on tubulin levels. * p < 0.05.Back to article page