Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome

Table 4 GO categories of the 55 chromosome 21 transcripts tightly regulated in DS and controls (CV ≤ 0.2)

GO term	Genes	%*	p-value	FE
Cofactor metabolic process	SOD1	9.5	0.0077	9.4
	FTCD
	PDXK
	CRYZL1
ATPase activity, coupled to transmembrane movement of substances	ATP5O	9.5	0.0018	15.9
	ATP5J
	ABCG1
Oxidative phosphorylation	ATP5O	7.1	0.016	14.9
	ATP5J
	NDUFV3
Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	ATP5O	4.8	0.016	120.4
	ATP5J	4.8	0.016	120.4
Regulation of cholesterol biosynthetic process	ABCG1	4.8	0.019	100.3
Regulation of cholesterol biosynthetic process	SOD1	4.8	0.019	100.3

ISSN: 1755-8794