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Table 4 GO categories of the 55 chromosome 21 transcripts tightly regulated in DS and controls (CV ≤ 0.2)

From: Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome

      GO term Genes %* p-value FE
Cofactor metabolic process SOD1 9.5 0.0077 9.4
FTCD
PDXK
CRYZL1
ATPase activity, coupled to transmembrane movement of substances ATP5O 9.5 0.0018 15.9
ATP5J
ABCG1
Oxidative phosphorylation ATP5O 7.1 0.016 14.9
ATP5J
NDUFV3
Mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) ATP5O 4.8 0.016 120.4
ATP5J
Regulation of cholesterol biosynthetic process ABCG1 4.8 0.019 100.3
SOD1
  1. FE fold enrichment, *% of genes in category.