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Table 5 Enriched pathways of the 55 chromosome 21 transcripts tightly regulated in DS and controls (CV ≤ 0.2)

From: Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome

   Pathway term

 Genes

 %

p-value

 FE

Parkinson’s disease

 ATP5O

 9.5

 0.002

13.8

 

 ATP5J

   
 

NDUFV3

   
 

 UBC6/7

   

Huntington’s disease

 ATP5O

 9.5

 0.0062

9.2

 

 ATP5J

   
 

NDUFV3

   
 

 SOD1

   

Oxidative phosphorylation

ATP5O

7.1

0.03

9.9

 

ATP5J

   
 

NDUFV3

   

Alzheimer’s disease

ATP5O

7.1

0.049

7.6

 

ATP5J

   
 

NDUFV3

   
  1. FE, fold enrichment.
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BMC Medical Genomics

ISSN: 1755-8794

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