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Table 5 Enriched pathways of the 55 chromosome 21 transcripts tightly regulated in DS and controls (CV ≤ 0.2)

From: Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome

   Pathway term  Genes  % p-value  FE
Parkinson’s disease  ATP5O  9.5  0.002 13.8
   ATP5J    
  NDUFV3    
   UBC6/7    
Huntington’s disease  ATP5O  9.5  0.0062 9.2
   ATP5J    
  NDUFV3    
   SOD1    
Oxidative phosphorylation ATP5O 7.1 0.03 9.9
  ATP5J    
  NDUFV3    
Alzheimer’s disease ATP5O 7.1 0.049 7.6
  ATP5J    
  NDUFV3    
  1. FE, fold enrichment.