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Table 6 Enriched GO categories of down-regulated genes (p < 0.01), sorted by p-value

From: Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome

   Biological process GO term N. of genes %* p-value FE
Ubiquitin metabolism ubiquitin-dependent protein catabolic process 16 5.4 5.2E-6 4.3
  modification-dependent protein catabolic process 25 8.5 1.4E-5 2.7
  proteolysis involved in cellular protein catabolic process 25 8.5 2.9E-5 2.6
  ligase activity 17 5.8 0.001 2.6
  proteolysis 29 9.8 0.009 1.6
  ubiquitin-protein ligase activity 8 2.7 0.013 3.2
  proteasomal ubiquitin-dependent protein catabolic process 6 2.0 0.025 3.6
Cell signalling positive regulation of I-kB kinase/NF-kB cascade 9 3.1 0.0002 5.5
  positive regulation of protein kinase cascade 10 3.4 0.0024 3.5
  positive regulation of signal transduction 12 4.1 0.01 2.4
Protein localization establishment of protein localization 25 8.5 0.002 2.0
Cell cycle mitotic cell cycle 14 4.7 0.008 2.3
  cell cycle phase 15 5.1 0.009 2.2
  M phase of mitotic cell cycle 10 3.4 0.013 2.7
  mitosis 9 3.1 0.031 2.4
  nuclear division 9 3.1 0.031 2.4
  interphase 6 2.0 0.033 3.3
Regulation of gene expression gene expression 62 21.0 0.022 1.3
  mRNA processing 12 4.1 0.023 2.2
  RNA splicing 11 3.7 0.024 2.3
Vescicle related ER to Golgi vesicle-mediated transport 4 1.4 0.033 5.6
  1. FE fold enrichment, *% of genes in category.