Table 6 Enriched GO categories of down-regulated genes (p < 0.01), sorted by p-value
Biological process | GO term | N. of genes | %* | p-value | FE |
|---|---|---|---|---|---|
Ubiquitin metabolism | ubiquitin-dependent protein catabolic process | 16 | 5.4 | 5.2E-6 | 4.3 |
modification-dependent protein catabolic process | 25 | 8.5 | 1.4E-5 | 2.7 | |
proteolysis involved in cellular protein catabolic process | 25 | 8.5 | 2.9E-5 | 2.6 | |
ligase activity | 17 | 5.8 | 0.001 | 2.6 | |
proteolysis | 29 | 9.8 | 0.009 | 1.6 | |
ubiquitin-protein ligase activity | 8 | 2.7 | 0.013 | 3.2 | |
proteasomal ubiquitin-dependent protein catabolic process | 6 | 2.0 | 0.025 | 3.6 | |
Cell signalling | positive regulation of I-kB kinase/NF-kB cascade | 9 | 3.1 | 0.0002 | 5.5 |
positive regulation of protein kinase cascade | 10 | 3.4 | 0.0024 | 3.5 | |
positive regulation of signal transduction | 12 | 4.1 | 0.01 | 2.4 | |
Protein localization | establishment of protein localization | 25 | 8.5 | 0.002 | 2.0 |
Cell cycle | mitotic cell cycle | 14 | 4.7 | 0.008 | 2.3 |
cell cycle phase | 15 | 5.1 | 0.009 | 2.2 | |
M phase of mitotic cell cycle | 10 | 3.4 | 0.013 | 2.7 | |
mitosis | 9 | 3.1 | 0.031 | 2.4 | |
nuclear division | 9 | 3.1 | 0.031 | 2.4 | |
interphase | 6 | 2.0 | 0.033 | 3.3 | |
Regulation of gene expression | gene expression | 62 | 21.0 | 0.022 | 1.3 |
mRNA processing | 12 | 4.1 | 0.023 | 2.2 | |
RNA splicing | 11 | 3.7 | 0.024 | 2.3 | |
Vescicle related | ER to Golgi vesicle-mediated transport | 4 | 1.4 | 0.033 | 5.6 |