Skip to main content

Table 2 Characteristics of epigenetic marks that were increased or decreased over 3 fold in the PANC-1 as compared to the hTERT-HPNE cell line

From: An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer

A. Epigenetic marks that were enriched or depleted in PANC-1 as compared to hTERT-HPNE pancreatic cells
   Increased in PANC-1 cells Decreased in PANC-1 cells
Mark Fold change # Increased % Increased # Decreased % Decreased
RNA Pol II ≥ 3 42,809 71.8% 16,841 28.2%
H3K4Me3 ≥ 3 4,434 53.7% 3,828 46.3%
H3K4me1 ≥ 3 13,999 26.1% 39,556 73.9%
H3K27Me3 ≥ 3 2,474 19.0% 10,521 81.0%
B. Differential epigenetic marks (change ≥ 3 fold) in the ALDH1A3 gene in PANC-1 and hTERT-HPNE pancreatic cell lines
  RNA Pol II H3K27me3
Gene symbol ALDH1A3 ALDH1A3
Chromosome chr15 chr15
Start (bp) 101,420,000 101,435,600
End (bp) 101,420,199 101,439,799
PANC-1 readcount 1.119 1.181
hTERT-HPNE readcount 0.065 5.404
Fold change 12.39 0.23
P value 1.08 x 10-13 8.55 x 10-24
FDR 3.16 x 10-13 1.27 x 10-22
  1. A. Number and percentages of epigenetic marks that were increased or decreased over 3 fold in the PANC-1 as compared to the hTERT-HPNE cell lines.
  2. B. Epigenetic marks in the ALDH1A3 gene are listed with location (NCBI build 37) of the respective epigenetic mark, normalized read counts, fold change and significance values (P value and False Discovery Rate, FDR).