Outlier-enriched pathways in the TGen data set. A) Heatmap marking outliers for each outlier-enriched pathway: neuron development, nitric oxide (NO) signaling, and skeletal development (Figure 4, step 4). Samples sorted by outlier status followed by diagnosis. B) Venn diagram showing the overlap of outlier samples for the three pathways in Figure 1A. The numbers of case and control outliers, respectively, are shown in parentheses. C) A comparison of Mahalanobis distance values (Figure 4, step 2) in neuron development and NO signaling. Marginal density plots show the distributions of case (red) and control (blue) samples.