Effects of cholestatic drugs on gene expression in mouse PCLS. PCLS obtained from 5 mice were treated with 40 μM cyclosporin A (CsA), 20 μM chlorpromazine (CPZ) or vehicle (DMSO) for 24 hours and subjected to Affymetrix microarray analysis. The biological processes in the heat map correspond to gene sets significantly affected according to GSEA analysis (p < 0.05, FDR < 0.25). Gene sets were obtained using the ANNI text mining tool. Processes that were up-regulated are represented by red color, the down-regulated processes are depicted in green, processes that were unchanged are depicted in black.