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Figure 3 | BMC Medical Genomics

Figure 3

From: Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes

Figure 3

Effects of cyclosporin A and chlorpromazine on the expression of genes involved in Fxr and Rxr-regulated pathways related to metabolism and/or transport of bile acids and lipids. Cyclosporin A (CsA) and chlorpromazine (CPZ) significantly affected Fxr-regulated cholesterol and bile acids cellular transport pathway (A), Bile acids regulation of glucose and lipid metabolism via Fxr (B), and Rxr-dependent regulation of lipid metabolism via Ppar, Rar and Vdr pathway (C). Blue and red bars indicate down-and up-regulation respectively of significantly affected genes. 1 and 2 indicate liver slices treated with CsA and CPZ respectively. Each bar represents average fold change of gene expression (treatment vs. control) in liver slices from five mice. ECM: extracellular matrix. For an explanation of the MetaCore symbols is referred to http://pathwaymaps.com/pdf/MC_legend.pdf.

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