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Table 2 Uniquely dysregulated genes in grothelial garcinoma versus normal urothelium

From: Gene profiling suggests a common evolution of bladder cancer subtypes

Gene Fold change UCa Function
MEST 8.14 Encodes a member of alpha/beta hydrolase superfamily; imprinting in cancer
EZH2 5.57 Stem cell related gene; previously reported as upregulated in UCa
CENPF 5.54 Component of centromere/kinetochore complex; affects chromosome segregation
GINS2 5.43 Psf2 homolog; complex component that regulates DNA replication in yeast
CLCA4 -11.9 Member of the calcium sensitive chloride conductance superfamily
POU2AF1 -8.96 Regulates TH1 and TH2 immune responses
IL33 -7.99 Member of IL1 family; enhances TH2 cytokine production
SEPP1 -6.94 Selenoprotein; may affect oxidative stress response
IL6 -6.57 Inflammatory cytokine; increased after BCG administration in the bladder
GPR171 -6.45 G protein-coupled receptor; may regulate hematopoietic progenitor cells
FOSB -6.26 One member of the AP-1 transcription factor complex; implicated in ovarian carcinoma
ITK -6.05 Regulator of T cell proliferation
AGR3 -5.62 May regulate protein folding; may regulate cisplatin resistance in ovarian cancer
CCL19 -5.45 Cytokine affecting B and T cell migration; may enhance B-cell mediated immunity;
CD36 -5.42 Thrombospondin receptor; may affect tumor vascularity and matrix content
DKK1 -5.33 Inhibits WNT signaling; may inhibit invasive behavior and self-renewal in some cancers
  1. Differentially expressed genes have an adjusted p value of <0.05.