Table 2 Uniquely dysregulated genes in grothelial garcinoma versus normal urothelium
From: Gene profiling suggests a common evolution of bladder cancer subtypes
Gene | Fold change UCa | Function |
|---|---|---|
MEST | 8.14 | Encodes a member of alpha/beta hydrolase superfamily; imprinting in cancer |
EZH2 | 5.57 | Stem cell related gene; previously reported as upregulated in UCa |
CENPF | 5.54 | Component of centromere/kinetochore complex; affects chromosome segregation |
GINS2 | 5.43 | Psf2 homolog; complex component that regulates DNA replication in yeast |
CLCA4 | -11.9 | Member of the calcium sensitive chloride conductance superfamily |
POU2AF1 | -8.96 | Regulates TH1 and TH2 immune responses |
IL33 | -7.99 | Member of IL1 family; enhances TH2 cytokine production |
SEPP1 | -6.94 | Selenoprotein; may affect oxidative stress response |
IL6 | -6.57 | Inflammatory cytokine; increased after BCG administration in the bladder |
GPR171 | -6.45 | G protein-coupled receptor; may regulate hematopoietic progenitor cells |
FOSB | -6.26 | One member of the AP-1 transcription factor complex; implicated in ovarian carcinoma |
ITK | -6.05 | Regulator of T cell proliferation |
AGR3 | -5.62 | May regulate protein folding; may regulate cisplatin resistance in ovarian cancer |
CCL19 | -5.45 | Cytokine affecting B and T cell migration; may enhance B-cell mediated immunity; |
CD36 | -5.42 | Thrombospondin receptor; may affect tumor vascularity and matrix content |
DKK1 | -5.33 | Inhibits WNT signaling; may inhibit invasive behavior and self-renewal in some cancers |