| Mutation alone | Methylation alone | Integrated data | |||
---|---|---|---|---|---|---|
Rank | Gene | Sign | Gene | Sign | Gene | Sign |
1 | TGFBR2 | ↑ | MLH1 | ↑ | MLH1 (methyl) | ↑ |
2 | CASP8 | ↑ | FLVCR2 | ↑ | PDE6B (mut) | ↑ |
3 | ACVR2A | ↑ | EFNA1 | ↓ | POLR1D (mut) | ↑ |
4 | MSH3 | ↑ | CDK12 | ↑ | FLVCR2 (methyl) | ↑ |
5 | MAP3K6 | ↑ | HOXC11 | ↓ | DAK (mRNA) | ↑ |
6 | GATA2 | ↑ | ZNF318 | ↑ | TGFBR2 (mut) | ↑ |
7 | MACF1 | ↑ | SEPT5 | ↑ | SEPT5 (methyl) | ↑ |
8 | BRAF | ↑ | MIER3 | ↑ | EFNA1 (methyl) | ↓ |
9 | GPHN | ↑ | ELK4 | ↓ | MLH1 (mRNA) | ↓ |
10 | MAEA | ↑ | SDHD | ↓ | STK32B (mut) | ↑ |