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Table 1 Validation results of each dataset and integration of 5 data sources

From: Integrating human omics data to prioritize candidate genes

  Artificial linkage interval Random control Whole genome
  TOP AUC FE MRR TOP AUC FE MRR TOP AUC FE MRR
ALL (Lasso) Leave one out 62.47% 90.86% 68.09 8.90% 57.42% 90.78% 57.42 8.34% 29.34% 90.21% 2616.84 7.57%
Ab initio 61.48% 90.61% 67.01 10.98% 56.58% 90.49% 56.58 8.87% 27.87% 89.16% 2484.89 8.09%
ALL (Regular) Leave one out 56.96% 89.92% 64.25 11.20% 53.69% 90.24% 53.69 9.98% 24.16% 89.01% 2154.80 8.72%
Ab initio 55.47% 89.52% 63.74 11.60% 52.64% 90.02% 52.64 9.65% 23.11% 88.16% 2061.20 9.22%
PPI Leave one out 47.41% 86.08% 51.66 16.94% 42.07% 82.23% 42.07 18.05% 9.87% 79.78% 880.31 19.46%
Ab initio 44.82% 84.45% 48.85 17.95% 39.29% 80.02% 39.29 20.29% 9.16% 79.05% 816.98 20.08%
KEGG Leave one out 42.16% 76.02% 46.20 16.36% 35.89% 73.12% 35.89 19.50% 11.48% 62.38% 1023.90 12.93%
Ab initio 41.02% 75.19% 44.91 16.52% 34.20% 71.31% 34.20 20.10% 11.20% 62.20% 998.93 13.01%
GS Leave one out 40.34% 79.08% 43.97 18.59% 40.20% 74.07% 40.20 15.80% 10.64% 67.26% 948.98 15.09%
Ab initio 40.27% 78.69% 43.89 18.80% 38.45% 72.73% 38.45 16.40% 10.31% 66.03% 919.55 15.65%
GE Leave one out 23.25% 74.30% 25.34 31.15% 17.44% 69.04% 17.44 29.51% 1.75% 67.61% 156.08 28.79%
Ab initio 22.97% 74.03% 25.04 31.48% 16.53% 68.60% 16.53 29.94% 1.47% 67.12% 131.11 29.21%
GO Leave one out 24.65% 76.99% 26.86 24.94% 20.24% 69.18% 22.24 23.51% 8.05% 61.74% 717.98 22.63%
Ab initio 24.00% 76.81% 26.16 25.08% 20.10% 68.89% 20.13 23.71% 7.47% 61.44% 666.25 22.95%