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Table 2 Significantly over-represented gene ontology biological processes associated with differentially expressed genes in the liver of mice supplemented with adequate levels of selenium and folate post-weaning (n = 6 per treatment)

From: Post-weaning selenium and folate supplementation affects gene and protein expression and global DNA methylation in mice fed high-fat diets

Term GOid Genename Systematicname Description Fold change P value
Multicellular organismal process GO:0032501 Il2 NM_008366 Mus musculus interleukin 2 −1.50 0.010
   Isl1 NM_021459 Mus musculus ISL1 transcription factor, LIM/homeodomain −1.59 0.007
   Mbp NM_010777 Mus musculus myelin basic protein, transcript variant 7 −1.62 0.004
   Ift172 NM_026298 Mus musculus intraflagellar transport 172 homolog (Chlamydomonas) −1.52 0.002
   Errfi1 NM_133753 Mus musculus ERBB receptor feedback inhibitor 1 1.73 0.000
   Dmbx1 NM_130865 Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1 −1.50 0.010
   Mcoln3 AK033008 Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA −1.68 0.008
   Ndrg4 NM_145602 Mus musculus N-myc downstream regulated gene 4 −1.55 0.009
   Frem2 NM_172862 Mus musculus Fras1 related extracellular matrix protein 2 −1.52 0.007
   Olfr1355 AF042360 Mus musculus clone OR27-3 putative olfactory receptor mRNA −1.53 0.001
   Olfr357 NM_146623 Mus musculus olfactory receptor 357 −1.52 0.008
   Olfr646 NM_147056 Mus musculus olfactory receptor 646 −1.67 0.010
Developmental process GO:0032502 Il2 NM_008366 Mus musculus interleukin 2 −1.50 0.010
   Isl1 NM_021459 Mus musculus ISL1 transcription factor, LIM/homeodomain −1.59 0.007
   Mbp NM_010777 Mus musculus myelin basic protein, transcript variant 7 −1.62 0.004
   Slc2a4 NM_009204 Mus musculus solute carrier family 2 (facilitated glucose transporter), member 4 −2.39 0.001
   Ift172 NM_026298 Mus musculus intraflagellar transport 172 homolog (Chlamydomonas) −1.52 0.002
   Errfi1 NM_133753 Mus musculus ERBB receptor feedback inhibitor 1 −1.73 0.000
   Dmbx1 NM_130865 Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1 1.50 0.010
   Mcoln3 AK033008 Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA −1.68 0.008
   Ndrg4 NM_145602 Mus musculus N-myc downstream regulated gene 4 −1.55 0.009
   Frem2 NM_172862 Mus musculus Fras1 related extracellular matrix protein 2 −1.52 0.007
   Il2 NM_008366 Mus musculus interleukin 2 −1.50 0.010
Multicellular organismal development GO:0007275 Isl1 NM_021459 Mus musculus ISL1 transcription factor, LIM/homeodomain −1.59 0.007
   Mbp NM_010777 Mus musculus myelin basic protein, transcript variant 7 −1.62 0.004
   Ift172 NM_026298 Mus musculus intraflagellar transport 172 homolog (Chlamydomonas) −1.52 0.002
   Errfi1 NM_133753 Mus musculus ERBB receptor feedback inhibitor 1 1.73 0.000
   Dmbx1 NM_130865 Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1 −1.50 0.010
   Mcoln3 AK033008 Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA −1.68 0.008
   Ndrg4 NM_145602 Mus musculus N-myc downstream regulated gene 4 −1.55 0.009
   Frem2 NM_172862 Mus musculus Fras1 related extracellular matrix protein 2 −1.52 0.007
Cellular process GO:0009987 Fpr-rs2 NM_008039 Mus musculus formyl peptide receptor, related sequence 2 1.51 0.005
   Il2 NM_008366 Mus musculus interleukin 2 −1.50 0.010
   Isl1 NM_021459 Mus musculus ISL1 transcription factor, LIM/homeodomain −1.59 0.007
   Mbp NM_010777 Mus musculus myelin basic protein, transcript variant 7 −1.62 0.004
   Slc2a4 NM_009204 Mus musculus solute carrier family 2 (facilitated glucose transporter), member 4 −2.39 0.001
   Ift172 NM_026298 Mus musculus intraflagellar transport 172 homolog (Chlamydomonas) −1.52 0.002
   Errfi1 NM_133753 Mus musculus ERBB receptor feedback inhibitor 1 1.73 0.000
   Pcdhb10 NM_053135 Mus musculus protocadherin beta 10 −1.52 0.005
   Dmbx1 NM_130865 Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1 −1.50 0.010
   Mcoln3 AK033008 Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA −1.68 0.008
   C79407 NM_172578 Mus musculus expressed sequence C79407 −1.66 0.005
   Spon1 AK084717 Mus musculus 13 days embryo heart cDNA −1.66 0.004
   Tnrc6a AK147327 Mus musculus cDNA −1.71 0.003
   Frem2 NM_172862 Mus musculus Fras1 related extracellular matrix protein 2 −1.52 0.007
   Olfr1355 AF042360 Mus musculus clone OR27-3 putative olfactory receptor −1.53 0.001
   Olfr357 NM_146623 Mus musculus olfactory receptor 357 −1.52 0.008
   Olfr646 NM_147056 Mus musculus olfactory receptor 646 −1.67 0.010
System development GO:0048731 Il2 NM_008366 Mus musculus interleukin 2 −1.50 0.010
   Isl1 NM_021459 Mus musculus ISL1 transcription factor, LIM/homeodomain −1.59 0.007
   Mbp NM_010777 Mus musculus myelin basic protein, transcript variant 7 −1.62 0.004
   Ift172 NM_026298 Mus musculus intraflagellar transport 172 homolog (Chlamydomonas) −1.52 0.002
   Errfi1 NM_133753 Mus musculus ERBB receptor feedback inhibitor 1 1.73 0.000
   Dmbx1 NM_130865 Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1 −1.50 0.010
   Mcoln3 AK033008 Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA −1.68 0.008
   Frem2 NM_172862 Mus musculus Fras1 related extracellular matrix protein 2 −1.52 0.007
   Il2 NM_008366 Mus musculus interleukin 2 −1.50 0.010
Organ development GO:0048513 Isl1 NM_021459 Mus musculus ISL1 transcription factor, LIM/homeodomain −1.59 0.007
   Mbp NM_010777 Mus musculus myelin basic protein, transcript variant 7 −1.62 0.004
   Ift172 NM_026298 Mus musculus intraflagellar transport 172 homolog (Chlamydomonas) −1.52 0.002
   Errfi1 NM_133753 Mus musculus ERBB receptor feedback inhibitor 1 1.73 0.000
   Dmbx1 NM_130865 Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1 −1.50 0.010
   Mcoln3 AK033008 Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA −1.68 0.008
   Frem2 NM_172862 Mus musculus Fras1 related extracellular matrix protein 2 −1.52 0.007
Cellular developmental process GO:0048869 Il2 NM_008366 Mus musculus interleukin 2 −1.50 0.010
   Isl1 NM_021459 Mus musculus ISL1 transcription factor, LIM/homeodomain −1.59 0.007
   Mbp NM_010777 Mus musculus myelin basic protein, transcript variant 7 −1.62 0.004
   Ift172 NM_026298 Mus musculus intraflagellar transport 172 homolog (Chlamydomonas) −1.52 0.002
   Errfi1 NM_133753 Mus musculus ERBB receptor feedback inhibitor 1 1.73 0.000
   Dmbx1 NM_130865 Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1 −1.50 0.010
   Mcoln3 AK033008 Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA −1.68 0.008
   Frem2 NM_172862 Mus musculus Fras1 related extracellular matrix protein 2 −1.52 0.007
Anatomical structure development GO:0048856 Il2 NM_008366 Mus musculus interleukin 2 −1.50 0.010
   Isl1 NM_021459 Mus musculus ISL1 transcription factor, LIM/homeodomain −1.59 0.007
   Mbp NM_010777 Mus musculus myelin basic protein, transcript variant 7 −1.62 0.004
   Ift172 NM_026298 Mus musculus intraflagellar transport 172 homolog (Chlamydomonas) −1.52 0.002
   Errfi1 NM_133753 Mus musculus ERBB receptor feedback inhibitor 1 1.73 0.000
   Dmbx1 NM_130865 Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1 −1.50 0.010
   Mcoln3 AK033008 Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA −1.68 0.008
   Frem2 NM_172862 Mus musculus Fras1 related extracellular matrix protein 2 −1.52 0.007
Negative regulation of macromolecule metabolic process GO:0010605 Il2 NM_008366 Mus musculus interleukin 2 −1.50 0.010
   Ift172 NM_026298 Mus musculus intraflagellar transport 172 homolog (Chlamydomonas) −1.52 0.002
   Errfi1 NM_133753 Mus musculus ERBB receptor feedback inhibitor 1 1.73 0.000
   Dmbx1 NM_130865 Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1 −1.50 0.010
   Tnrc6a AK147327 Mus musculus cDNA −1.71 0.003
Cell surface receptor linked signaling pathway GO:0007166 Il2 NM_008366 Mus musculus interleukin 2 −1.50 0.010
   Ift172 NM_026298 Mus musculus intraflagellar transport 172 homolog (Chlamydomonas) −1.52 0.002
   Plce1 AK035546 Mus musculus adult male urinary bladder cDNA 1.53 0.010
   Errfi1 NM_133753 Mus musculus ERBB receptor feedback inhibitor 1 1.73 0.000
   Olfr1355 AF042360 Mus musculus clone OR27-3 putative olfactory receptor −1.53 0.001
   Olfr357 NM_146623 Mus musculus olfactory receptor 357 −1.52 0.008
   Olfr646 NM_147056 Mus musculus olfactory receptor 646 −1.67 0.010
  1. A positive fold change indicates that supplementation increased the expression of the gene.