Post-weaning selenium and folate supplementation affects gene and protein expression and global DNA methylation in mice fed high-fat diets

Bermingham, Emma N; Bassett, Shalome A; Young, Wayne; Roy, Nicole C; McNabb, Warren C; Cooney, Janine M; Brewster, Di T; Laing, William A; Barnett, Matthew PG

doi:10.1186/1755-8794-6-7

Table 2 Significantly over-represented gene ontology biological processes associated with differentially expressed genes in the liver of mice supplemented with adequate levels of selenium and folate post-weaning (n = 6 per treatment)

From: Post-weaning selenium and folate supplementation affects gene and protein expression and global DNA methylation in mice fed high-fat diets

Term	GOid	Genename	Systematicname	Description	Fold change	P value
Multicellular organismal process	GO:0032501	Il2	NM_008366	Mus musculus interleukin 2	−1.50	0.010
		Isl1	NM_021459	Mus musculus ISL1 transcription factor, LIM/homeodomain	−1.59	0.007
		Mbp	NM_010777	Mus musculus myelin basic protein, transcript variant 7	−1.62	0.004
		Ift172	NM_026298	Mus musculus intraflagellar transport 172 homolog (Chlamydomonas)	−1.52	0.002
		Errfi1	NM_133753	Mus musculus ERBB receptor feedback inhibitor 1	1.73	0.000
		Dmbx1	NM_130865	Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1	−1.50	0.010
		Mcoln3	AK033008	Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA	−1.68	0.008
		Ndrg4	NM_145602	Mus musculus N-myc downstream regulated gene 4	−1.55	0.009
		Frem2	NM_172862	Mus musculus Fras1 related extracellular matrix protein 2	−1.52	0.007
		Olfr1355	AF042360	Mus musculus clone OR27-3 putative olfactory receptor mRNA	−1.53	0.001
		Olfr357	NM_146623	Mus musculus olfactory receptor 357	−1.52	0.008
		Olfr646	NM_147056	Mus musculus olfactory receptor 646	−1.67	0.010
Developmental process	GO:0032502	Il2	NM_008366	Mus musculus interleukin 2	−1.50	0.010
		Isl1	NM_021459	Mus musculus ISL1 transcription factor, LIM/homeodomain	−1.59	0.007
		Mbp	NM_010777	Mus musculus myelin basic protein, transcript variant 7	−1.62	0.004
		Slc2a4	NM_009204	Mus musculus solute carrier family 2 (facilitated glucose transporter), member 4	−2.39	0.001
		Ift172	NM_026298	Mus musculus intraflagellar transport 172 homolog (Chlamydomonas)	−1.52	0.002
		Errfi1	NM_133753	Mus musculus ERBB receptor feedback inhibitor 1	−1.73	0.000
		Dmbx1	NM_130865	Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1	1.50	0.010
		Mcoln3	AK033008	Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA	−1.68	0.008
		Ndrg4	NM_145602	Mus musculus N-myc downstream regulated gene 4	−1.55	0.009
		Frem2	NM_172862	Mus musculus Fras1 related extracellular matrix protein 2	−1.52	0.007
		Il2	NM_008366	Mus musculus interleukin 2	−1.50	0.010
Multicellular organismal development	GO:0007275	Isl1	NM_021459	Mus musculus ISL1 transcription factor, LIM/homeodomain	−1.59	0.007
		Mbp	NM_010777	Mus musculus myelin basic protein, transcript variant 7	−1.62	0.004
		Ift172	NM_026298	Mus musculus intraflagellar transport 172 homolog (Chlamydomonas)	−1.52	0.002
		Errfi1	NM_133753	Mus musculus ERBB receptor feedback inhibitor 1	1.73	0.000
		Dmbx1	NM_130865	Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1	−1.50	0.010
		Mcoln3	AK033008	Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA	−1.68	0.008
		Ndrg4	NM_145602	Mus musculus N-myc downstream regulated gene 4	−1.55	0.009
		Frem2	NM_172862	Mus musculus Fras1 related extracellular matrix protein 2	−1.52	0.007
Cellular process	GO:0009987	Fpr-rs2	NM_008039	Mus musculus formyl peptide receptor, related sequence 2	1.51	0.005
		Il2	NM_008366	Mus musculus interleukin 2	−1.50	0.010
		Isl1	NM_021459	Mus musculus ISL1 transcription factor, LIM/homeodomain	−1.59	0.007
		Mbp	NM_010777	Mus musculus myelin basic protein, transcript variant 7	−1.62	0.004
		Slc2a4	NM_009204	Mus musculus solute carrier family 2 (facilitated glucose transporter), member 4	−2.39	0.001
		Ift172	NM_026298	Mus musculus intraflagellar transport 172 homolog (Chlamydomonas)	−1.52	0.002
		Errfi1	NM_133753	Mus musculus ERBB receptor feedback inhibitor 1	1.73	0.000
		Pcdhb10	NM_053135	Mus musculus protocadherin beta 10	−1.52	0.005
		Dmbx1	NM_130865	Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1	−1.50	0.010
		Mcoln3	AK033008	Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA	−1.68	0.008
		C79407	NM_172578	Mus musculus expressed sequence C79407	−1.66	0.005
		Spon1	AK084717	Mus musculus 13 days embryo heart cDNA	−1.66	0.004
		Tnrc6a	AK147327	Mus musculus cDNA	−1.71	0.003
		Frem2	NM_172862	Mus musculus Fras1 related extracellular matrix protein 2	−1.52	0.007
		Olfr1355	AF042360	Mus musculus clone OR27-3 putative olfactory receptor	−1.53	0.001
		Olfr357	NM_146623	Mus musculus olfactory receptor 357	−1.52	0.008
		Olfr646	NM_147056	Mus musculus olfactory receptor 646	−1.67	0.010
System development	GO:0048731	Il2	NM_008366	Mus musculus interleukin 2	−1.50	0.010
		Isl1	NM_021459	Mus musculus ISL1 transcription factor, LIM/homeodomain	−1.59	0.007
		Mbp	NM_010777	Mus musculus myelin basic protein, transcript variant 7	−1.62	0.004
		Ift172	NM_026298	Mus musculus intraflagellar transport 172 homolog (Chlamydomonas)	−1.52	0.002
		Errfi1	NM_133753	Mus musculus ERBB receptor feedback inhibitor 1	1.73	0.000
		Dmbx1	NM_130865	Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1	−1.50	0.010
		Mcoln3	AK033008	Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA	−1.68	0.008
		Frem2	NM_172862	Mus musculus Fras1 related extracellular matrix protein 2	−1.52	0.007
		Il2	NM_008366	Mus musculus interleukin 2	−1.50	0.010
Organ development	GO:0048513	Isl1	NM_021459	Mus musculus ISL1 transcription factor, LIM/homeodomain	−1.59	0.007
		Mbp	NM_010777	Mus musculus myelin basic protein, transcript variant 7	−1.62	0.004
		Ift172	NM_026298	Mus musculus intraflagellar transport 172 homolog (Chlamydomonas)	−1.52	0.002
		Errfi1	NM_133753	Mus musculus ERBB receptor feedback inhibitor 1	1.73	0.000
		Dmbx1	NM_130865	Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1	−1.50	0.010
		Mcoln3	AK033008	Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA	−1.68	0.008
		Frem2	NM_172862	Mus musculus Fras1 related extracellular matrix protein 2	−1.52	0.007
Cellular developmental process	GO:0048869	Il2	NM_008366	Mus musculus interleukin 2	−1.50	0.010
		Isl1	NM_021459	Mus musculus ISL1 transcription factor, LIM/homeodomain	−1.59	0.007
		Mbp	NM_010777	Mus musculus myelin basic protein, transcript variant 7	−1.62	0.004
		Ift172	NM_026298	Mus musculus intraflagellar transport 172 homolog (Chlamydomonas)	−1.52	0.002
		Errfi1	NM_133753	Mus musculus ERBB receptor feedback inhibitor 1	1.73	0.000
		Dmbx1	NM_130865	Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1	−1.50	0.010
		Mcoln3	AK033008	Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA	−1.68	0.008
		Frem2	NM_172862	Mus musculus Fras1 related extracellular matrix protein 2	−1.52	0.007
Anatomical structure development	GO:0048856	Il2	NM_008366	Mus musculus interleukin 2	−1.50	0.010
		Isl1	NM_021459	Mus musculus ISL1 transcription factor, LIM/homeodomain	−1.59	0.007
		Mbp	NM_010777	Mus musculus myelin basic protein, transcript variant 7	−1.62	0.004
		Ift172	NM_026298	Mus musculus intraflagellar transport 172 homolog (Chlamydomonas)	−1.52	0.002
		Errfi1	NM_133753	Mus musculus ERBB receptor feedback inhibitor 1	1.73	0.000
		Dmbx1	NM_130865	Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1	−1.50	0.010
		Mcoln3	AK033008	Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA	−1.68	0.008
		Frem2	NM_172862	Mus musculus Fras1 related extracellular matrix protein 2	−1.52	0.007
Negative regulation of macromolecule metabolic process	GO:0010605	Il2	NM_008366	Mus musculus interleukin 2	−1.50	0.010
		Ift172	NM_026298	Mus musculus intraflagellar transport 172 homolog (Chlamydomonas)	−1.52	0.002
		Errfi1	NM_133753	Mus musculus ERBB receptor feedback inhibitor 1	1.73	0.000
		Dmbx1	NM_130865	Mus musculus diencephalon/mesencephalon homeobox 1, transcript variant 1	−1.50	0.010
		Tnrc6a	AK147327	Mus musculus cDNA	−1.71	0.003
Cell surface receptor linked signaling pathway	GO:0007166	Il2	NM_008366	Mus musculus interleukin 2	−1.50	0.010
		Ift172	NM_026298	Mus musculus intraflagellar transport 172 homolog (Chlamydomonas)	−1.52	0.002
		Plce1	AK035546	Mus musculus adult male urinary bladder cDNA	1.53	0.010
		Errfi1	NM_133753	Mus musculus ERBB receptor feedback inhibitor 1	1.73	0.000
		Olfr1355	AF042360	Mus musculus clone OR27-3 putative olfactory receptor	−1.53	0.001
		Olfr357	NM_146623	Mus musculus olfactory receptor 357	−1.52	0.008
		Olfr646	NM_147056	Mus musculus olfactory receptor 646	−1.67	0.010

A positive fold change indicates that supplementation increased the expression of the gene.

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ISSN: 1755-8794

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