Detecting differentially methylated loci for Illumina Array methylation data based on human ovarian cancer data

BMC Medical Genomics

Table 1 Estimated type I error rates at significance level 0.05 with 10000 replicates.

Distribution (sample sizes, parameters)	ANOVA	median	Welch	KW
Beta (s = 30,30,30, a = 1,1,1, b = 2,2,2)	0.048	0.040	0.052	0.047
Beta (s = 30,30,30, a = 1,1,1, b = 10,10,10)	0.052	0.044	0.053	0.051
Beta (s = 30,30,30, a = 10,10,10, b = 1,1,1)	0.047	0.044	0.052	0.048
Beta (s = 30,30,30, a = 10,10,10, b = 10,10,10)	0.045	0.045	0.047	0.046
Beta (s = 20,30,40, a = 1,1,1, b = 2,2,2)	0.053	0.052	0.050	0.053
Beta (s = 20,30,40, a = 1,1,1, b = 10,10,10)	0.049	0.049	0.054	0.048
Beta (s = 20,30,40, a = 10,10,10, b = 1,1,1)	0.045	0.049	0.056	0.044
Beta (s = 20,30,40, a = 10,10,10, b = 10,10,10)	0.050	0.051	0.043	0.052
TN (s = 30,30,30, μ = 0.5,0.5, 0.5, σ² = 0.1,0.1,0.1)	0.050	0.044	0.053	0.045
TN(s = 30,30,30, μ = 0.5, 0.5, 0.5, σ² = 0.1,0.2,0.3)	0.053	0.067	0.047	0.053
TN (s = 20,30,40, μ = 0.5, 0.5, 0.5, σ² = 0.1,0.1,0.1)	0.050	0.052	0.052	0.049
TN(s = 20,30,40, μ = 0.5, 0.5, 0.5, σ² = 0.1,0.2,0.3)	0.047	0.054	0.051	0.043

ISSN: 1755-8794