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Table 2 Gene ontology terms of CMT-related functional modules revealed by network ontology analysis.

From: Integrative analysis of congenital muscular torticollis: from gene expression to clinical significance

Module GO domain GO term Related interaction p-value
Module 2 BP developmental process DCN-ELN, ELN-FBN1, ELN-FBN2, DCN-FBN1, FBN1-FBN2 0.0839
Module 3 BP cell division SEPT2-SEPT7, SEPT2-SEPT6, SEPT6-SEPT7 0.0503
  BP cell cycle SEPT2-SEPT7, SEPT2-SEPT6, SEPT6-SEPT7 0.0503
  CC septin complex SEPT2-SEPT7, SEPT2-SEPT6, SEPT6-SEPT7 0.0503
  CC cell cortex part SEPT2-SEPT7, SEPT2-SEPT6, SEPT6-SEPT7 0.0503
Module 4 BP signaling ITGB1-ITGB5, ITGA5-ITGB1, ITGB1-TNC, ITGA8-ITGB1, ITGA5-ITGB5, ITGA5-TNC, ITGA8-TNC 0.0091
  BP response to stimulus ITGB1-PXN, ITGA5-ITGB1, ITGB1-TNC, ITGA8-ITGB1, ITGA5-TNC, ITGA8-TNC 0.0521
  BP biological adhesion PARVA-PXN, ITGB1-PXN, ITGB5-PXN, ITGB1-ITGB5, COL6A3-ITGB1, ITGA5-ITGB1, ITGB1-TNC, ITGA8-ITGB1, ITGA5-ITGB5, COL6A3-ITGA5, ITGA5-TNC, ITGA8-TNC 0.0768
  BP cell adhesion PARVA-PXN, ITGB1-PXN, ITGB5-PXN, ITGB1-ITGB5, COL6A3-ITGB1, ITGA5-ITGB1, ITGB1-TNC, ITGA8-ITGB1, ITGA5-ITGB5, COL6A3-ITGA5, ITGA5-TNC, ITGA8-TNC 0.0768
  BP signaling pathway ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5 0.0845
  BP cell-substrate adhesion ITGB1-PXN, ITGB5-PXN, ITGB1-ITGB5, ITGA8-ITGB1 0.0845
  BP cell-matrix adhesion ITGB1-PXN, ITGB5-PXN, ITGB1-ITGB5, ITGA8-ITGB1 0.0845
  BP cell surface receptor linked signaling pathway ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5 0.0845
  BP integrin-mediated signaling pathway ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5 0.0845
  CC integral to membrane ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5 0.0621
  CC intrinsic to membrane ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5 0.0621
  CC receptor complex ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5 0.0621
  CC integrin complex ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5 0.0621
  MF signal transducer activity ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5 0.0621
  MF receptor activity ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5 0.0621
  MF molecular transducer activity ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5 0.0621
Module 5 CC postsynaptic density DLG2-ERBB4, DLG2-DLG4, DLG4-ERBB4 0.0116
  CC cytoskeletal part DLG2-ERBB4, DLG2-DLG4, DLG4-ERBB4 0.0116
  CC synapse part DLG2-ERBB4, DLG2-DLG4, DLG4-ERBB4 0.0116
  1. Only GO terms of which p-values were less than 0.1 were listed. GO, Gene Ontology; BP, biological process; MF, molecular function; CC, cellular component