Integrative analysis of congenital muscular torticollis: from gene expression to clinical significance

Yim, Shin-Young; Yoon, Dukyong; Park, Myong Chul; Lee, Il Jae; Kim, Jang-Hee; Lee, Myung Ae; Kwack, Kyu-Sung; Lee, Jan-Dee; Lee, Jeong-Hun; Soh, Euy-Young; Na, Young-In; Park, Rae Woong; Lee, KiYoung; Jun, Jae-Bum

doi:10.1186/1755-8794-6-S2-S10

BMC Medical Genomics

Table 2 Gene ontology terms of CMT-related functional modules revealed by network ontology analysis.

From: Integrative analysis of congenital muscular torticollis: from gene expression to clinical significance

Module	GO domain	GO term	Related interaction	p-value
Module 2	BP	developmental process	DCN-ELN, ELN-FBN1, ELN-FBN2, DCN-FBN1, FBN1-FBN2	0.0839
Module 3	BP	cell division	SEPT2-SEPT7, SEPT2-SEPT6, SEPT6-SEPT7	0.0503
	BP	cell cycle	SEPT2-SEPT7, SEPT2-SEPT6, SEPT6-SEPT7	0.0503
	CC	septin complex	SEPT2-SEPT7, SEPT2-SEPT6, SEPT6-SEPT7	0.0503
	CC	cell cortex part	SEPT2-SEPT7, SEPT2-SEPT6, SEPT6-SEPT7	0.0503
Module 4	BP	signaling	ITGB1-ITGB5, ITGA5-ITGB1, ITGB1-TNC, ITGA8-ITGB1, ITGA5-ITGB5, ITGA5-TNC, ITGA8-TNC	0.0091
	BP	response to stimulus	ITGB1-PXN, ITGA5-ITGB1, ITGB1-TNC, ITGA8-ITGB1, ITGA5-TNC, ITGA8-TNC	0.0521
	BP	biological adhesion	PARVA-PXN, ITGB1-PXN, ITGB5-PXN, ITGB1-ITGB5, COL6A3-ITGB1, ITGA5-ITGB1, ITGB1-TNC, ITGA8-ITGB1, ITGA5-ITGB5, COL6A3-ITGA5, ITGA5-TNC, ITGA8-TNC	0.0768
	BP	cell adhesion	PARVA-PXN, ITGB1-PXN, ITGB5-PXN, ITGB1-ITGB5, COL6A3-ITGB1, ITGA5-ITGB1, ITGB1-TNC, ITGA8-ITGB1, ITGA5-ITGB5, COL6A3-ITGA5, ITGA5-TNC, ITGA8-TNC	0.0768
	BP	signaling pathway	ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5	0.0845
	BP	cell-substrate adhesion	ITGB1-PXN, ITGB5-PXN, ITGB1-ITGB5, ITGA8-ITGB1	0.0845
	BP	cell-matrix adhesion	ITGB1-PXN, ITGB5-PXN, ITGB1-ITGB5, ITGA8-ITGB1	0.0845
	BP	cell surface receptor linked signaling pathway	ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5	0.0845
	BP	integrin-mediated signaling pathway	ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5	0.0845
	CC	integral to membrane	ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5	0.0621
	CC	intrinsic to membrane	ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5	0.0621
	CC	receptor complex	ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5	0.0621
	CC	integrin complex	ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5	0.0621
	MF	signal transducer activity	ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5	0.0621
	MF	receptor activity	ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5	0.0621
	MF	molecular transducer activity	ITGB1-ITGB5, ITGA5-ITGB1, ITGA8-ITGB1, ITGA5-ITGB5	0.0621
Module 5	CC	postsynaptic density	DLG2-ERBB4, DLG2-DLG4, DLG4-ERBB4	0.0116
	CC	cytoskeletal part	DLG2-ERBB4, DLG2-DLG4, DLG4-ERBB4	0.0116
	CC	synapse part	DLG2-ERBB4, DLG2-DLG4, DLG4-ERBB4	0.0116

Only GO terms of which p-values were less than 0.1 were listed. GO, Gene Ontology; BP, biological process; MF, molecular function; CC, cellular component

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ISSN: 1755-8794

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