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Table 3 Analysis with simulated variants in GLI3 and CAV2

From: BioBin: a bioinformatics tool for automating the binning of rare variants using publicly available biological knowledge

Gene MAF Thres Location Size Loci # Bins # Sig. Bins Overall Rank Unadj. P-val* Adj. P-val
GLI3 0.02 7:42000547-42276618 276kb 262 1539 0 1377 0.9828 1
GLI3 0.05    431 1692 0 1288 0.7723 1
GLI3 0.10    602 1730 0 1273 0.7404 1
CAV2 0.02 7:116139654-116148595 109kb 9 1612 1 1 1.731e-17 2.791e-14
CAV2 0.05    11 1701 1 1 2.338e-14 3.976e-1
CAV2 0.10    20 1735 0 3 0.0005869 1
  1. A simulated variant was added to two genes, GLI3 and CAV2. The genes were used to test signal mitigation in the presence of a large versus small number of variants in the bin. The adjusted p-values were calculated using a Bonferroni correction to account for the total number of bins generated.