Detecting early-warning signals of type 1 diabetes and its leading biomolecular networks by dynamical network biomarkers

Table 1 Number of genes and interaction pairs with high correlations between DNB and pathways.

Pathway name	Time points	The first DNB			The second DNB
		DNB	pathway	pairs	DNB	pathway	pairs
T cell receptor signaling pathway	Critical point	93	32	493	96	7	327
	Disease onset point	89	105	677	93	107	844
NF-kappa B signaling pathway	Critical point	94	28	372	96	9	425
	Disease onset point	92	87	588	89	87	705
Insulin signaling pathway	Critical point	95	31	606	59	5	152
	Disease onset point	94	133	839	93	134	1023

The column item "DNB" represents the number of genes in DNB which are highly correlated with the pathway in corresponding time point, the item "pathway" denotes the number of genes in the pathway which are highly correlated with the DNB in corresponding time point, and the item "pairs" means number of gene pairs which are highly correlated between genes separately in DNB and pathway in the corresponding time point.

ISSN: 1755-8794