Mutational signatures in 9 types of cancer. X-axis denotes the 96 trinucleotide substitutions. Y-axis denotes the relative coefficient of each substitution to the corresponding signature (the matrix W
, see the main text). For each cancer, the plot in each panel represents one detected signature. HNSCC: head and neck squamous cell carcinoma. LUAD: lung adenocarcinoma. TCGA_BRCA: the breast cancer data from TCGA. TCGA_CRC: colon and rectal cancer. TCGA_EC: endometrial carcinoma. TCGA_GBM: glioblastoma. TCGA_OvCa: ovarian carcinoma. TCGA_SQCC: squamous cell lung cancer.