Childhood abuse is associated with methylation of multiple loci in adult DNA

BMC Medical Genomics

Table 2 Selected functional analysis of abuse associated hypo- and hypermethylation

Pathway/function	Number of genes in pathway/function	Differentially methylated		Hypo-methylated			Hyper-methylated
Pathway/function	Number of genes in pathway/function	n	p	n	p	fdr	n	p	fdr
WNT signaling pathway	142	19	0.0013	15	0.0020	0.53	4	0.22	1
Regulation	2330	169	0.017	134	0.0018	0.51	33	0.88	1
- Chromatin modification	273	32	0.0004	28	0.00005	0.09	4	0.68	1
- Histone modification	105	13	0.013	11	0.008	0.94	2	0.53	1
- Transcription factor binding	493	41	0.034	35	0.006	0.84	6	0.84	1
Development	3054	230	0.0007	172	0.00096	0.40	58	0.17	1
- Multicellular organismal development	2838	213	0.0012	163	0.0006	0.32	50	0.32	1
Cell surface receptor linked signal transduction	1778	125	0.071	79	0.60	1	46	0.002	0.53

‘n’ is the number of genes in the relevant pathway that are differentially methylated in association with abuse.
‘p’ was calculated using the hypergeometric test, it indicates the statistical significance of the enrichment.
‘fdr’ the false discovery rate (FDR) corresponding to the p-value.

ISSN: 1755-8794