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Table 2 Selected functional analysis of abuse associated hypo- and hypermethylation

From: Childhood abuse is associated with methylation of multiple loci in adult DNA

Pathway/function Number of genes in pathway/function Differentially methylated Hypo-methylated Hyper-methylated
n p n p fdr n p fdr
WNT signaling pathway 142 19 0.0013 15 0.0020 0.53 4 0.22 1
Regulation 2330 169 0.017 134 0.0018 0.51 33 0.88 1
- Chromatin modification 273 32 0.0004 28 0.00005 0.09 4 0.68 1
- Histone modification 105 13 0.013 11 0.008 0.94 2 0.53 1
- Transcription factor binding 493 41 0.034 35 0.006 0.84 6 0.84 1
Development 3054 230 0.0007 172 0.00096 0.40 58 0.17 1
- Multicellular organismal development 2838 213 0.0012 163 0.0006 0.32 50 0.32 1
Cell surface receptor linked signal transduction 1778 125 0.071 79 0.60 1 46 0.002 0.53
  1. ‘n’ is the number of genes in the relevant pathway that are differentially methylated in association with abuse.
  2. ‘p’ was calculated using the hypergeometric test, it indicates the statistical significance of the enrichment.
  3. ‘fdr’ the false discovery rate (FDR) corresponding to the p-value.