Table 2 Pathways discriminating patients developing delayed graft function (DGF) from those having early graft function (EGF) at the time of transplantation (T0)

UP-REGULATED IN DGF

NLS bearing substrate import into nucleus

13

CBLB, FYB, KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6, KPNB1, NCKIPSD, RANBP5, RERE, TRPS1

<0.001

Nuclear transport

89

AKT1, ALS2CR2, ANP32A, ATXN1, BARD1, BAT1, BCL3, BCL6, CALR, CBLB, CDH1, DDX19B, DDX25, DDX39, DUSP16, EIF5A, F2, F2R, FAF1, FLNA, FYB, GLI3, GSK3B, HNRNPA1, HRB, HTATIP2, KHDRBS1, KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6, KPNB1, LYK5, MALT1, MCM3AP, MDFI, MXI1, MYBBP1A, NCBP2, NCKIPSD, NF1, NFKBIE, NFKBIL1, NFKBIL2, NLRP12, NLRP3, NOP5/NOP58, NPM1, NUDT4, NUP107, NUP133, NUP160, NUP205, NUP214, NUP98, NUPL2, NXF5PDIA3, PPIH, PPP1R10, PTTG1IP, RAE1, RANBP2, RANBP5, RERE, RPAIN, SMAD3, SMG1, SMG5, SMG6, SMG7, TBRG1, TGFB1, TNF, TNFSF14, TNPO1, TPR, TRIP6, TRPS1, TSC1, UHMK1, UPF1, UPF2, XPO6, XPO7, ZFYVE9

0.004

Nucleocytoplasmic transport

88

AKT1, ALS2CR2, ANP32A, ATXN1, BARD1, BAT1, BCL3, BCL6, CALR, CBLB, CDH1, DDX19B, DDX25, DDX39, DUSP16, EIF5A, F2, F2R, FAF1, FLNA, FYB, GLI3, GSK3B, HNRNPA1, HRB, HTATIP2, KHDRBS1, KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6, KPNB1, LYK5, MALT1, MCM3AP, MDFI, MXI1, MYBBP1A, NCBP2, NCKIPSD, NF1, NFKBIE, NFKBIL1, NFKBIL2, NLRP12, NLRP3, NOP5/NOP58, NPM1, NUDT4, NUP107, NUP133, NUP160, NUP205, NUP214, NUP98, NUPL2, NXF5PDIA3, PPIH, PPP1R10, PTTG1IP, RAE1, RANBP2, RANBP5, RERE, RPAIN, SMAD3, SMG1, SMG5, SMG6, SMG7, TGFB1, TNF, TNFSF14, TNPO1, TPR, TRIP6, TRPS1, TSC1, UHMK1, UPF1, UPF2, XPO6, XPO7, ZFYVE9

0.004

Protein import into nucleus

48

AKT1, BCL3, BCL6, CBLB, CDH1, CEP57, F2, F2R, FAF1, FLNA, FYB, GLI3, KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6, KPNB1, MCM3AP, MDFI, MXI1, NCKIPSD, NF1, NFKBIE, NFKBIL1, NFKBIL2, NLRP12, NLRP3, NOP5/NOP58, NUP205, PDIA3, PPIH, PPP1R10, PTTG1IP, RANBP2, RANBP5, RERE, RPAIN, SMAD3, TGFB1, TNF, TNFSF14, TNPO1, TPR, TRIP6, TRPS1, ZFYVE9

0.004

Ribonucleotide metabolic process

16

ACLY, ADK, ADSS, AK5, AMPD3, C16orf7, CMPK, CTNS, CTPS, ENTPD4, FIGNL1, GUK1, NDUFS1, NUDT5, OLA1, UMPS

0.004

Nuclear import

50

AKT1, BCL3, BCL6, CBLB, CDH1, CEP57, F2, F2R, FAF1, FLNA, FYB, GLI3, HNRNPA1, HTATIP2, KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6, KPNB1, MCM3AP, MDFI, MXI1, NCKIPSD, NF1, NFKBIE, NFKBIL1, NFKBIL2, NLRP12, NLRP3, NOP5/NOP58, NUP205, PDIA3, PPIH, PPP1R10, PTTG1IP, RANBP2, RANBP5, RERE, RPAIN, SMAD3, TGFB1, TNF, TNFSF14, TNPO1, TPR, TRIP6, TRPS1, ZFYVE9

0.006

Pyrimidine nucleotide metabolic process

10

AK5, CMPK, CTPS, DCK, DCTD, ENTPD4, NT5C, NT5M, TYMP, UMPS

0.006

Macromolecule localization

237

ABCA1, ABCG1, ACHE, AGXT, AIP, AKAP10, AKT1, ALS2CR2, ANG, ANGPTL3, AP1G1, AP1GBP1, AP1M2, AP3B1, AP3D1, AP3M1, AP3S2, APBA1, APOA1, APOA2, APPBP2, ARCN1, ARFGAP3, ARFIP1, ARL4D, ATG4A, ATG4B, ATG4C, ATG4D, BACE2, BARD1, BAT1, BCL3, BCL6, BIN3, BIRC5, C3orf31, CADM1, CALR, CANX, CARD8, CBLB, CBY1, CD24, CD3G, CD74, CD81, CDC37, CDH1, CEP290, CEP57, CIDEA, CKAP5, COG2, COG3, COG7, COLQ, COX18, CRTAM, CTSA, CUTA, DDX19B, DDX25, DDX39, DERL1, DERL2, DNAJC1, DPH3, DUSP16, EGFR, EIF5A, ERCC3, ERP29, F2, F2R, FAF1, FLNA, FOXP3, FYB, GABARAP, GGA1, GGN, GLI3, GLMN, GSK3B, HNRNPA2B1, HOMER3, HPS4, HRB, ICMT, INS, KDELR1, KDELR2, KHDRBS1, KIF13B, KLHL2, KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6, KPNB1, LGTN, LMAN2L, LRP1B, LTBP2, LYK5, MAL, MCM3AP, MDFI, MFN2, MIPEP, MXI1, MYH9, MYO6, NAGPA, NCBP2, NCKIPSD, NF1, NFKBIE, NFKBIL1, NFKBIL2, NLGN1, NLRC4, NLRP12, NLRP2, NLRP3, NOD2, NOP5/NOP58, NPM1, NUDT4, NUP107, NUP133, NUP160, NUP205, NUP214, NUPL2, NXF5, OPTN, PDIA2, PDIA3, PDIA4, PEX1, PEX10, PEX12, PEX13, PEX14, PEX16, PEX19, PEX26, PEX3, PEX6, PEX7, PPIH, PPP1R10, PPT1, PPY, PTTG1IP, PYCARD, PYDC1, RAB35, RAB3GAP2, RAE1, RANBP2, RANBP5, REEP1, RERE, RPAIN, RPGR, RPL11, RTP1, RTP2, RTP3, RTP4, SCG2, SCG5, SEC23IP, SEC63, SELS, SERGEF, SHROOM2, SHR

0.008

DOWN-REGULATED IN DGF

Vasculature development

55

ACVRL1, AGGF1, AMOT, ANG, ANGPTL3, ANGPTL4, ATPIF1, BTG1, C1GALT1, CANX, CCM2, CDH13, CHRNA7, COL4A2, COL4A3, CUL7, EGF, EGFL7, EMCN, EPGN, ERAP1, FOXC2, FOXO4, GLMN, HTATIP2, IL17F, IL18, IL8, MYH9, NCL, NF1, NOTCH4, NPPB, NPR1, PDPN, PF4, PLG, PML, PROK2, RASA1, RHOB, RNH1, ROBO4, RUNX1, SCG2, SERPINF1, SHH, SPHK1, SPINK5, STAB1, TGFB2, THY1, TNFSF12, TNNI3, VEGFA

0.005

Activation of protein kinase activity

28

ALS2CR2, ANG, AZU1, CARD10, CARTPT, CCDC88A, CHRM1, EDN2, GADD45B, GADD45G, GAP43, IRAK1, LYK5, MALT1, MAP3K13, MAP3K4, MAP3K7, MAP3K7IP1, PARD3, PICK1, PPAP2A, PRKD3, TAOK2, TNFSF15, TRAF2, TRAF6, TRAF7, ZAK

0.006

Regulation of angiogenesis

26

AGGF1, AMOT, ANGPTL3, ANGPTL4, BTG1, CHRNA7, COL4A2, COL4A3, FOXO4, HTATIP2, IL17F, NF1, NPPB, NPR1, PF4, PLG, PML, RHOB, RNH1, RUNX1, SERPINF1, SPHK1, SPINK5, STAB1, TNFSF12, TNNI3

0.006

G PROTEIN Signaling coupled to IP3 phospholipase C activating

45

AGTR1, ANG, AVPR1A, AVPR1B, AZU1, C5AR1, CALCA, CCKAR, CCKBR, CHRM1, CHRM2, DRD1, DRD2, EDG2, EDG4, EDG6, EDN2, EDNRA, EDNRB, EGFR, F2RL3, GAP43, GNA15, GNAQ, GRM5, HOMER1, HRH1, HTR2B, IL8RB, LTB4R, MC3R, NMBR, NMUR1, NMUR2, P2RY1, P2RY11, P2RY2, P2RY4, P2RY6, PARD3, PICK1, PLCB2, PPAP2A, PRKD3, TACR1

0.007

Phosphoinositide mediated signaling

48

AGTR1, ANG, AVPR1A, AVPR1B, AZU1, C5AR1, CALCA, CCKAR, CCKBR, CHRM1, CHRM2, DRD1, DRD2, EDG2, EDG4, EDG6, EDN2, EDNRA, EDNRB, EGFR, F2RL3, GAP43, GNA15, GNAQ, GRM5, HOMER1, HRH1, HTR2B, IL8RB, LTB4R, MC3R, NMBR, NMUR1, NMUR2, P2RY1, P2RY11, P2RY2, P2RY4, P2RY6, PARD3, PICK1, PLCB2, PLCE1, PLCH1, PPAP2A, PRKD3, PTAFR, TACR1

0.007

Phospholipase C activation

14

ANG, AVPR1A, AVPR1B, C5AR1, CCKBR, EDG2, EDG4, EDG6, EDNRA, EGFR, GNA15, GNAQ, NMUR1, PLCB2

0.008

Regulation of myeloid cell differentiation

19

ACIN1, ACVR1B, ACVR2A, CALCA, CARTPT, CDK6, ETS1, FOXO3, IL4, INHA, INHBA, LDB1, MAFB, PF4, RUNX1, SCIN, SPI1, ZBTB16, ZNF675

0.009