A genetic variant in the LDLRpromoter is responsible for part of the LDL-cholesterol variability in primary hypercholesterolemia

Table 2 Polymorphisms analyzed in PH and normolipemic populations by iPlex technology

	Polygenic hypercholesterolemia				Controls
Polymorphisms	Zaragoza N=252	Barcelona N=127	AWHS N=98	Total N=477	AWHS N=525	P value
rs17242346 (g.3724G>A)	0.107	0.071	0.122	0.100	0.080	0.113
rs17242739 (g.3627C>A)	0.000	0.008	0.000	0.000	0.000	0.280
rs17248720 (g.3131C>T)	0.090	0.083	0.102	0.090	0.160	< 0.0001
rs17249120 (g.4440G>A)	0.004	0.000	0.020	0.003	0.010	0.082

AWHS, Aragon Workers’ Health Study. Zaragoza, Barcelona and AWHS were the three hypercholesterolemic populations analyzed. Variables were compared using χ² test. Genotype prevalences were estimated as observed proportions.

ISSN: 1755-8794