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Table 2 Correlation between changes in SNORA12 gene expression and DNA methylation during infection with clinical characteristics of our study populations

From: Human rhinovirus infection causes different DNA methylation changes in nasal epithelial cells from healthy and asthmatic subjects

  Healthy (n = 13) Asthma (n = 16) Both Groups
  Expression Methylation Expression Methylation Expression Methylation
  rs p value rs p value rs p value rs p value rs p value rs p value
Atopy 0.16 0.59 0.12 0.69 0.20 0.47 0.17 0.53 0.26 0.18 -0.09 0.63
FEV1 (% predicted) -0.36 0.22 0.37 0.21 0.71 0.002 0.00 0.99 0.11 0.59 0.27 0.15
FEV1/FVC (L) -0.57 0.04 -0.09 0.76 0.43 0.10 0.23 0.39 -0.12 0.55 0.29 0.13
PEF (L/min) -0.08 0.80 -0.08 0.79 -0.13 0.64 -0.04 0.88 -0.08 0.68 0.00 1.00
Nasal Allergies -0.22 0.50 0.39 0.21 0.08 0.78 -0.02 0.95 0.13 0.51 -0.17 0.39
Chronic Rhinosinusitis 0.06 0.84 0.32 0.30 -0.15 0.58 -0.06 0.84 -0.05 0.81 0.10 0.61
Albuterol use n/a n/a n/a n/a -0.29 0.28 0.07 0.80 -0.01 0.96 -0.21 0.27
  1. FEV1 – forced expiratory volume in one second. FVC – forced vital capacity. PEF – Peak expiratory Flow. rs – spearmans rho.
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BMC Medical Genomics

ISSN: 1755-8794

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